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Diagnosis & Tests for Renal Cell Cancer

Doctors use many tests to find, or diagnose, cancer. They also do tests to learn if cancer has spread to other parts of the body from where the cancer originated. A biopsy is the only certain way to confirm a diagnosis of cancer. When performing a biopsy, the doctor takes a sample of tissue for testing in a laboratory.

When a kidney cancer is suspected, a kidney imaging study is obtained. The initial imaging study is usually an ultrasound or CT scan. If cancer is suspected, the patient should be evaluated to determine the extent of spread or stage of the cancer. Examination of both kidneys is essential to assure that one is working normally.

Staging of Kidney Cancer

When diagnosed with renal cell cancer further tests are necessary to determine the extent of spread (stage) of the cancer. Cancer’s stage is a key factor in determining the best treatment. The stage of cancer may be determined at the time of diagnosis or it may be necessary to perform additional tests.

Intravenous pyelogram (IVP): An IVP is a procedure which involves the injection of dye (contrast) into the blood. When the contrast travels through the kidneys and ureters, it allows these organs to be visualized with X-rays (fluoroscopy).

Ultrasound: A procedure in which high-energy sound waves (ultrasound) are bounced off internal organs and tissues and make echoes. The echoes form a picture of body tissues called a sonogram.

Imaging tests: Tests such as X-rays, CT scans, magnetic resonance imaging (MRI) and positron emission tomography (PET) are used to help determine the stage and whether the cancer has spread.

  • Computed Tomography (CT) Scan: A CT scan is a technique for imaging body tissues and organs, during which X-ray transmissions are converted to detailed images, using a computer to synthesize X-ray data. A CT scan is conducted with a large machine positioned outside the body that can rotate to capture detailed images of the organs and tissues inside the body.
  • Magnetic Resonance Imaging (MRI): MRI uses a magnetic field rather than X-rays, and can often distinguish more accurately between healthy and diseased tissue than a CT. An MRI gives a better picture of cancer located near bone than does CT, does not use radiation, and provides pictures from various angles that enable doctors to construct a three-dimensional image of the cancer.
  • Positron emission tomography (PET): Positron emission tomography scanning is an advanced technique for imaging body tissues and organs. One characteristic of living tissue is the metabolism of sugar. Prior to a PET scan, a substance containing a type of sugar attached to a radioactive isotope (a molecule that emits radiation) is injected into the patient’s vein. The cancer cells “take up” the sugar and attached isotope, which emits positively charged, low energy radiation (positrons) that create the production of gamma rays that can be detected by the PET machine to produce a picture. If no gamma rays are detected in the scanned area, it is unlikely that the mass in question contains living cancer cells.

Bone Scan: A test to check if there are cancer cells, in the bone. A very small amount of radioactive material is injected into a vein and travels through the bloodstream. The radioactive material collects in the bones and is detected by a scanner.

Precision Medicine & Personalized Cancer Care

Not all kidney cancer cells are alike. They may differ from one another based on what genes have mutations that are responsible for the growth of the cancer. Testing is performed to identify genetic mutations or the proteins they produce that drive the growth of the cancer. Once a genetic abnormality is identified, a specific targeted therapy can be designed to attack a specific mutation or other cancer-related change in the DNA programming of the cancer cells. Precision cancer medicine uses targeted drugs and immunotherapies engineered to directly attack the cancer cells with specific abnormalities, leaving normal cells largely unharmed.1,2,3 Patients should discuss the role of genomic-biomarker testing for the management of their cancer with their treating oncologist.

Stages of Renal Cell (kidney) Cancer

Staging is ultimately confirmed by surgical removal of the cancer and exploration of the area adjacent to the kidney. The following are simplified definitions of the various stages of kidney cancer. Click on a stage for an overview of the most recent information available concerning the comprehensive treatment of renal cell cancer.

Stage I: The primary cancer is 7 centimeters (about 3 inches) or less and is limited to the kidney, with no spread to lymph nodes or distant sites.

Stage II: The primary cancer is greater than 7 centimeters (about 3 inches) and is limited to the kidney, with no spread to lymph nodes or distant sites.

Stage III: The cancer has spread to the regional lymph nodes but not to distant sites in the body, and/or extends to the renal veins or vena cava (large vein returning blood to the heart located in the middle of the abdomen near the back).

Stage IV: The cancer has spread to distant sites or invades directly beyond the local area.

Next: Treatment & Management of Kidney Cancer



1 https://www.pfizer.com/news/press-release/press-release-detail/fda_approves_bavencio_avelumab_plus_inlyta_axitinib_combination_for_patients_with_advanced_renal_cell_carcinoma

2 https://news.cancerconnect.com/renal-cancer/keytruda-inlyta-treatment-combination-improves-outcomes-in-renal-cell-caner-if0p6hIV90a85b7HnRNxzA/

3 https://news.bms.com/press-release/corporatefinancial-news/checkmate-214-study-evaluating-opdivo-combination-yervoy-stopp

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Caregiver Tips FACT SHEET

Every patient is surrounded by caregivers that stand with them in the cancer fight to make the hard times easier. The role of caregivers is vital, and they want to do their best. It’s also important for caregivers to take care of themselves. Keeping these tips in mind can help caregivers as they care for patients.

Mike Diers

Patient Story: Mike Diers

“A lot of people look at cancer as if they’re walking in a dark tunnel toward a pinprick of light,” said Mike. “It’s better to reverse that and enjoy the present and all the light that’s around you right now.”