Title:
STAR: Ph2 Futibatinib in FGFR2 Cholangiocarcinoma
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Description: TAS-120-205: Phase 2 Study of Futibatinib 20 mg and 16 mg in Patients with Advanced Cholangiocarcinoma with FGFR2 Fusions or Rearrangements
Indication:
Biliary Cancer
Location:
Texas Oncology-Amarillo Cancer Center
Phase: II
Title:
Ph3 GDC-9545 ER+ HER2- BC (lidERA)
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Description: A PHASE III RANDOMIZED OPEN-LABEL MULTICENTER STUDY EVALUATING THE EFFICACY AND SAFETY OF ADJUVANT GIREDESTRANT COMPARED WITH PHYSICIAN'S CHOICE OF ADJUVANT ENDOCRINE MONOTHERAPY IN PATIENTS WITH ESTROGEN RECEPTOR-POSITIVE HER2-NEGATIVE EARLY BREAST CANCER (GO42784)
Indication:
Breast Cancer
Location:
Texas Oncology-Amarillo Cancer Center
Phase: III
Title:
STAR Ph1/2 PC14586 TP53 Y220C mut Solid Tumors (PYNNACLE)
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Description: A Phase 1/2 Open-label Multicenter Study to Assess the Safety Tolerability Pharmacokinetics Pharmacodynamics and Efficacy of PC14586 in Patients with Locally Advanced or Metastatic Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE) (PMV-586-101)
Indication:
Breast Cancer
Location:
Texas Oncology-Amarillo Cancer Center
Phase: I/II
Title:
Ph3 Saci Govi Pembro vs PC TNBC (ASCENT-05 / OptimICE-RD)
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Description: GS-US-595-6184: A Randomized Open-label Phase 3 Study of Adjuvant Sacituzumab Govitecan and Pembrolizumab Versus Treatment of Physicians Choice in Patients with Triple Negative Breast Cancer Who Have Residual Invasive Disease After Surgery and Neoadjuvant Therapy (ASCENT-05/OptimICE-RD)
Indication:
Breast Cancer
Location:
Texas Oncology-Amarillo Cancer Center
Phase: III
Title:
Ph3 Deruxtecan with Durvalumab vs Pembrolizumab 3neg BC (Tropion Breast 04)
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Description: A Phase III Open-Label Randomized Study of Neoadjuvant Datopotamab Deruxtecan (Dato-DXd) Plus Durvalumab Followed by Adjuvant Durvalumab With or Without Chemotherapy Versus Neoadjuvant Pembrolizumab Plus Chemotherapy Followed by Adjuvant Pembrolizumab With or Without Chemotherapy for the Treatment of Adult Patients with Previously Untreated Triple-Negative or Hormone Receptor-low/HER2-negative Breast Cancer (D926QC00001)
Indication:
Breast Cancer
Location:
Texas Oncology-Amarillo Cancer Center
Phase: III
Title:
Ph3 Durvalumab & PDL1+ Dato-DXd vs Pembrolizumab BC (TROPION-Breast05)
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Description: A Phase III Open-label Randomised Study of Datopotamab Deruxtecan (Dato-DXd) with or without Durvalumab compared with Investigator's Choice of Chemotherapy (Paclitaxel/Nab-paclitaxel or Gemcitabine+ Carboplatin) in combination with Pembrolizumab in Patients with PD-L1 Positive Locally Recurrent Inoperable or Metastatic Triple-negative Breast Cancer (TROPIONBreast05)(D7630C00001)
Indication:
Breast Cancer
Location:
Texas Oncology-Amarillo Cancer Center
Phase: III
Title:
Ph3 Adjuvant Endocrine Therapy Camizestrant (AZD9833) in ER+/HER2- Early Breast Cancer (CAMBRIA-2)
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Description: CAMBRIA-2: A Phase III Open-Label Randomised Study to Assess the Efficacy and Safety of Camizestrant (AZD9833 a Next Generation Oral Selective Estrogen Receptor Degrader) vs Standard Endocrine Therapy (Aromatase Inhibitor or Tamoxifen) as Adjuvant Treatment for Patients With ER+/HER2- Early Breast Cancer and an Intermediate-high or High risk of Recurrence Who Have Completed Definitive Locoregional Treatment and Have No Evidence of Disease (D8535C00001)
Indication:
Breast Cancer
Location:
Texas Oncology-Amarillo Cancer Center
Phase: III
Title:
ACCELERO: Ph3 study of HER2-positive controlled by physicians with metastatic breast cancer
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Description: A Phase 3 randomized open-label multicenter controlled study to evaluate the efficacy and safety of zanidatamab in combination with physician's choice chemotherapy compared to trastuzumab in combination with physician's choice chemotherapy for the treatment of participants with metastatic HER2-positive breast cancer who have progressed on or are intolerant to previous trastuzumab deruxtecan treatment (JZP598-303)
Indication:
Breast Cancer
Location:
Texas Oncology-Amarillo Cancer Center
Phase: III
Title:
STAR Ph1/2 PC14586 TP53 Y220C mut Solid Tumors (PYNNACLE)
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Description: A Phase 1/2 Open-label Multicenter Study to Assess the Safety Tolerability Pharmacokinetics Pharmacodynamics and Efficacy of PC14586 in Patients with Locally Advanced or Metastatic Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE) (PMV-586-101)
Indication:
Endometrial Cancer
Location:
Texas Oncology-Amarillo Cancer Center
Phase: I/II
Title:
Ph3 Study of Volrustomig (MEDI5752) Advanced-HNSCC LA-HNSCC (eVOLVE-HNSCC)
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Description: A Phase III Randomized Open-Label Multi-Center Global Study of Volrustomig as Sequential Therapy Versus Observation in Participants with Unresected Locally Advanced-Head and Neck Squamous Cell Carcinoma (LA-HNSCC) Who Have Not Progressed Following Definitive Concurrent Chemoradiotherapy (eVOLVE-HNSCC) D798EC00001
Indication:
Head and Neck Cancer
Location:
Texas Oncology-Amarillo Cancer Center
Phase: III
Title:
STAR Ph3 study to evaluate to treat patients with HNSCC
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Description: A phase 3 open-label randomized controlled study to evaluate the efficacy and safety of petosemtamab compared with investigator's choice monotherapy treatment in previously treated patients with incurable metastatic/recurrent head and neck squamous cell carcinoma (MCLA-158-CL02)
Indication:
Head and Neck Cancer
Location:
Texas Oncology-Amarillo Cancer Center
Phase: III
Title:
Ph2 MRTX849 Pembro NSCLC KRAS
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Description: A Phase 2 Trial of Adagrasib Monotherapy and in Combination with Pembrolizumab and a Phase 3 Trial of Adagrasib in Combination with Pembrolizumab versus Pembrolizumab in Patients with Advanced Non-Small Cell Lung Cancer with KRAS G12C Mutation (849-007)
Indication:
Lung Cancer
Location:
Texas Oncology-Amarillo Cancer Center
Phase: II/III
Title:
STAR Ph1/2 PC14586 TP53 Y220C mut Solid Tumors (PYNNACLE)
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Description: A Phase 1/2 Open-label Multicenter Study to Assess the Safety Tolerability Pharmacokinetics Pharmacodynamics and Efficacy of PC14586 in Patients with Locally Advanced or Metastatic Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE) (PMV-586-101)
Indication:
Lung Cancer
Location:
Texas Oncology-Amarillo Cancer Center
Phase: I/II
Title:
Ph3 SGN-B6A vs docetaxel NSCLC
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Description: A randomized phase 3 open-label study to evaluate sigvotatug vedotin compared with docetaxel in adult participants with previously treated non-small cell lung cancer (Be6A Lung-01)
Indication:
Lung Cancer
Location:
Texas Oncology-Amarillo Cancer Center
Phase: III
Title:
Ph 1b/ 3 Taze w/ R2 R/R Fol Lymph
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Description: A PHASE 1B/3 DOUBLE-BLIND RANDOMIZED ACTIVE-CONTROLLED 3-STAGE BIOMARKER ADAPTIVE STUDY OF TAZEMETOSTAT OR PLACEBO IN COMBINATION WITH LENALIDOMIDE PLUS RITUXIMAB IN SUBJECTS WITH RELAPSED/REFRACTORY FOLLICULAR LYMPHOMA (EZH-302)
Indication:
Lymphomas
Location:
Texas Oncology-Amarillo Cancer Center
Phase: I
Title:
A Phase 3b Study of BMS-986346 in Lower-risk Myelodisplastic Syndrome Participants
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Description: A Phase 3b Open-label Study Evaluating the Efficacy and Safety of Luspatercept (BMS-986346/ACE-536) Initiated at Maximum Approved Dose in LR-MDS with IPSS-R Very Low- Low- or Intermediate-risk Who Require RBC Transfusions (MAXILUS) (CA056-1060)
Indication:
Myelodysplastic Syndrome
Location:
Texas Oncology-Amarillo Cancer Center
Phase: III
Title:
STAR Ph2 study of AK117 in combo with azacitidine in patients with myelodysplastic syndromes
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Description: A randomized double-blind placebo-controlled multicenter phase 2 study of AK117/placebo in combination with azacitidine in patients with newly diagnosed higher-risk myelodysplastic syndrome (AK117-205)
Indication:
Myelodysplastic Syndrome
Location:
Texas Oncology-Amarillo Cancer Center
Phase: II
Title:
Ph3 study comparing CC-92480 in subjects with RRMM (SUCCESSOR-1)
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Description: A Phase 3 Two-Stage Randomized Multicenter Open-Label Study Comparing Mezigdomide (CC-92480) Bortezomib and Dexamethasone (MEZIVd) Versus Pomalidomide Bortezomib and Dexamethasone (PVd) in Subjects with Relapsed or Refractory Multiple Myeloma (RRMM):Successor-1 (CA057-001)
Indication:
Myelomas
Location:
Texas Oncology-Amarillo Cancer Center
Phase: III
Title:
STAR Ph1/2 PC14586 TP53 Y220C mut Solid Tumors (PYNNACLE)
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Description: A Phase 1/2 Open-label Multicenter Study to Assess the Safety Tolerability Pharmacokinetics Pharmacodynamics and Efficacy of PC14586 in Patients with Locally Advanced or Metastatic Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE) (PMV-586-101)
Indication:
Ovarian Cancer
Location:
Texas Oncology-Amarillo Cancer Center
Phase: I/II
Title:
Ph3 study of Rina-S versus treatment of investigator choice with ovarian cancer
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Description: A Phase 3 Randomized Open-label Study of Rinatabart Sesutecan (Rina-S) versus Treatment of Investigators Choice (IC) in Patients with Platinum Resistant Ovarian Cancer (GCT1184-02)
Indication:
Ovarian Cancer
Location:
Texas Oncology-Amarillo Cancer Center
Phase: III
Title:
Ph3 AZD5305 vs Placebo in Men with Metastatic Castration-sensitive Prostate Cancer
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Description: A Randomized 2-cohort Double-blind Placebo-controlled Phase III Study of Saruparib (AZD5305) in Combination with Physician's Choice New Hormonal Agents in Patients with HRRm and non-HRRm Metastatic Castration-Sensitive Prostate Cancer (EvoPAR-Prostate01) D9723C00001
Indication:
Prostate Cancer
Location:
Texas Oncology-Amarillo Cancer Center
Phase: III
Title:
STAR Ph1/2 PC14586 TP53 Y220C mut Solid Tumors (PYNNACLE)
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Description: A Phase 1/2 Open-label Multicenter Study to Assess the Safety Tolerability Pharmacokinetics Pharmacodynamics and Efficacy of PC14586 in Patients with Locally Advanced or Metastatic Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE) (PMV-586-101)
Indication:
Solid Tumors
Location:
Texas Oncology-Amarillo Cancer Center
Phase: I/II
Title:
Ph1/2 FIH RO1184 FOLR1 Select Solid Tumors
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Description: Phase 1/2 Study of Rina-S in Patients with Locally Advanced and/or Metastatic Solid Tumors GCT1184-01 (PRO1184-001)
Indication:
Solid Tumors
Location:
Texas Oncology-Amarillo Cancer Center
Phase: I/II
Title:
STAR Clinical Study to Further Evaluate Trametinib with rare BRAF V600E or met Solid Tumors
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Description: Clinical Study To Further Evaluate The Efficacy Of Dabrafenib Plus Trametinib In Patients With Rare BRAF V600E Mutation-Positive Unresectable or Metastatic Solid Tumors (CDRB436IIC01)
Indication:
Solid Tumors
Location:
Texas Oncology-Amarillo Cancer Center
Phase: IV