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San Antonio Publications

A list of recent publications related to cancer research conducted by our San Antonio physicians.

Date
Physicians
Publication
Title
    Leleu X, Martin TG, Einsele H, Lyons RM, Durie BGM, Iskander KS, Ailawadhi
    Clinical Lymphoma, Myeloma and Leukemia
    Role of Proteasome Inhibitors in Relapsed and/or Refractory Multiple Myeloma
    Khorana AA, Soff GA, Kakkar AK, Vadhan-Raj S, Riess H, Wun T, Streiff MB, Garcia DA, Liebman HA, Belani CP, O'Reilly EM, Patel JN, Yimer HA, Wildgoose P, Burton P, Vijapurkar U, Kaul S, Eikelboom J, McBane R, Bauer KA, Kuderer NM, Lyman GH; CASSINI Investigators
    The New England Journal of Medicine
    Rivaroxaban for Thromboprophylaxis in High-Risk Ambulatory Patients with Cancer
    Brano Djenic, M.D.
    American Society of Colon and Rectal Surgeons
    Treatment of Obstructive Sigmoid Fecaloma with Coca-Cola Enemas in an Adult Patients. Poster presentation at the annual scientific meeting in Nashville, TN.
    Brano Djenic, M.D.
    Ohio Valley Society of Colorectal Surgery
    Rectal Prolapse Recurrence Following Ventral Mesh Rectopexy Can Be Minimized if Anterior Compartment Defects are Thoroughly Evaluated and Treated. First place podium presentation OVSCRS annual meeting in Indianapolis, IN.
    Komrokji R, Swern AS, Grinblatt D, Lyons RM, Tobiasson M, Silverman LR, Sayar H, Vij R, Fliss A, Tu N, Sugrue MM.
    Oncologist
    Azacitidine in Lower-Risk Myelodysplastic Syndromes: A Meta-Analysis of Data from Prospective Studies
    Connors JM, Jurczak W, Straus DJ, Ansell SM, Kim WS, Gallamini A, Younes A, Alekseev S, Illés Á, Picardi M, Lech-Maranda E, Oki Y, Feldman T, Smolewski P, Savage KJ, Bartlett NL, Walewski J, Chen R, Ramchandren R, Zinzani PL, Cunningham D, Rosta A, Josephson NC, Song E, Sachs J, Liu R, Jolin HA, Huebner D, Radford J; ECHELON-1 Study Group.
    The New England Journal of Medicine
    Brentuximab Vedotin with Chemotherapy for Stage III or IV Hodgkin's Lymphoma.
    Mesa R, Vannucchi AM, Yacoub A, Zachee P, Garg M, Lyons R, Koschmieder S, Rinaldi C, Byrne J, Hasan Y, Passamonti F, Verstovsek S, Hunter D, Jones MM, Zhen H, Habr D, Martino B.
    British Journal of Haematology
    The efficacy and safety of continued hydroxycarbamide therapy versus switching to ruxolitinib in patients with polycythaemia vera: a randomized, double-blind, double-dummy, symptom study (RELIEF)
    Berenson J, Manges R, Badarinath S, Cartmell A, McIntyre K, Lyons R, Harb W, Mohamed H, Nourbakhsh A, Rifkin R.
    American Journal of Hematology 
    A phase 2 safety study of accelerated elotuzumab infusion, over less than 1 hour, in combination with lenalidomide and dexamethasone, in patients with multiple myeloma
    Fenaux P, Muus P, Kantarjian H, Lyons RM, Larson RA, Sekeres MA, Becker PS, Orejudos A, Franklin J.
    British Journal of Haematology
    Romiplostim monotherapy in thrombocytopenic patients with myelodysplastic syndromes: long-term safety and efficacy
    Garcia-Manero G, Montalban-Bravo G, Berdeja JG, Abaza Y, Jabbour E, Essell J, Lyons RM, Ravandi F, Maris M, Heller B, DeZern AE, Babu S, Wright D, Anz B, Boccia R, Komrokji RS, Kuriakose P, Reeves J, Sekeres MA, Kantarjian HM, Ghalie R, Roboz GJ
    Cancer
    Phase 2, randomized, double-blind study of pracinostat in combination with azacitidine in patients with untreated, higher-risk myelodysplastic syndromes
    Bersabe AR, Aden JK, Shumway NM, Osswald MB
    Journal of Clinical and Diagnostic Research
    Peripheral Smear Review and Bone Marrow Biopsy Correlation

    Download full publication here.

    Cines DB, Wasser J, Rodeghiero F, Chong BH, Steurer M, Provan D, Lyons R, Garcia-Chavez J, Carpenter N, Wang X, Eisen M.
    Haematologica
    Safety and efficacy of romiplostim in splenectomized and nonsplenectomized patients with primary immune thrombocytopenia.
    Verstovsek S, Mesa RA, Gotlib J, Gupta V, DiPersio JF, Catalano JV, Deininger MW, Miller CB, Silver RT, Talpaz M, Winton EF, Harvey JH Jr, Arcasoy MO, Hexner EO, Lyons RM, Paquette R, Raza A, Jones M, Kornacki D, Sun K, Kantarjian H; COMFORT-I investigators.
    Journal of Hematology and Oncology
    Long-term treatment with ruxolitinib for patients with myelofibrosis: 5-year update from the randomized, double-blind, placebo-controlled, phase 3 COMFORT-I trial.
    Roger M. Lyons, M.D., FACP
    Leukemia Research
    Relation Between Chelation and Clinical Outcomes in Lower-Risk Patients with Myelodysplastic Syndromes
    Moncrief S, Djenic B, Davis J, VanderVenle J, Hasham S, Kassir A
    Open Access Journal of Surgery
    Minimally Invasive Colorectal Surgery and Beyond: A Large, Singe-Surgeon Comparison Study Between Robotic and Laparoscopic Colorectal Resection to Evaluate and Define the Role and Application of New Technology
    Weitz JI, Lensing AWA, Prins MH, Bauersachs R, Beyer-Westendorf J, Bounameaux H, Brighton TA, Cohen AT, Davidson BL, Decousus H, Freitas MCS, Holberg G, Kakkar AK, Haskell L, van Bellen B, Pap AF, Berkowitz SD, Verhamme P, Wells PS, Prandoni P; EINSTEIN CHOICE Investigators
    The New England Journal of Medicine
    Rivaroxaban or Aspirin for Extended Treatment of Venous Thromboembolism.
    James R. Berenson, Alan Cartmell, Alberto Bessudo, Roger M. Lyons, Wael A. Harb, Dimitrios Tzachanis, Morton Coleman, Ralph V. Boccia, Robert M. Rifkin, Priti Patel, Sandra Dixon, Jesus G. Berdeja.
    Blood
    CHAMPION-1, a phase I/II study of once-weekly carfilzomib with dexamethasone for relapsed or refractory multiple myeloma.
    Mittendorf E.A., Ardavanis A., Symanowski J., Murray J.L., Shumway N.M., Litton J.K., Hale D.F., Perez S.A., Anastasopoulou E.A., Pistamaltzian N.F., Ponniah S., Baxevanis C.N., von Hofe E., Papamichail M., Peoples G.E.
    Annals of Oncology
    Primary analysis of a prospective, randomized, single-blinded phase II trial evaluating the HER2 peptide AE37 vaccine in breast cancer patients to prevent recurrence.
    Jackson, D and Perez, S and Hale, D and Greene, J and Schneble, E and Martin, J and Flores, M and Berry, J and Trappey, A and Vreeland, TJ, Hardin MO, Clifton GT, Herbert GS, Shumway, N, Papamichail M, Mittendorf EA, Peoples GE
    Annals of Surgical Oncology
    Correlation Between Preexisting Immunity and Clinical Response in a Phase II Trial Using HER2-Based Peptide Vaccines to Prevent Breast Cancer Recurrence
    Vreeland TJ, Jackson DO, Hale DF, Greene JM, Schneble EJ, Martin J, Flores M, Berry JS, Trappey AF, Hardin MO, Clifton GT, Herbert GS, Perez S, Shumway N, Papamichail M, Peoples GE, Mittendorf EA.
    Annals of Surgical Oncology
    Efficacy of Booster Inoculations in a Phase II Trial of GP2, a HER2-Derived Peptide Vaccine, for the Prevention of Breast Cancer Recurrence
    Hardin MO, Jackson DO, Hale DF, Greene JM, Schneble EJ, Martin J, Flores M, Berry JS, Trappey AF, Vreeland TJ, Clifton GT, Herbert GS, von Hofe E, Perez S, Shumway N, Papamichail M, Peoples GE, Mittendorf EA. 
    Annals of Surgical Oncology
    Impact of Boosting in the Phase II Trial of the AE37+ GM-CSF Vaccine in High-risk Breast Cancer Patients to Prevent Recurrence
    Djenic B, Ahmad RA, Breen RE, Hayman AV, O’Brien DP, Whiteford MH
    American Society of Colon and Rectal Surgeons
    Avoiding Emergent Surgery: Phenol Sclerotherapy for Acute Inpatient Hemorrhoidal Bleeding. Annual Scientific Meeting in Los Angeles, CA.
    Wilks, Sharon T. & Schnadig, Ian
    Future Oncology
    APF530 (Granisetron Inj Extended-Release) in a Three-Drug Regimen for Delayed CINV in Highly Emetogenic Chemotherapy
    Knolhoff JK, Hsu CH, Nodora J, Martinez ME, Bouton ME, Djenic B, Komenaka IK
    Medical Care and Research Review
    Patient Related Factors Associated with Rate of Missed Appointments
    Chiu L., Chow R., Popovic M., Navari R.M., Shumway N.M., Chiu N., Lam H., Milakovic M., Pasetka M., Vuong S., Chow E., DeAngelis C.
    Support Care Cancer
    Efficacy of olanzapine for the prophylaxis and rescue of chemotherapy-induced nausea and vomiting (CINV): a systematic review and meta-analysis.
    Raskob GE, van Es N, Segers A, Angchaisuksiri P, Oh D, Boda Z, Lyons RM, Meijer K, Gudz I, Weitz JI, Zhang G, Lanz H, Mercuri MF, Büller HR; Hokusai-VTE investigators.
    The Lancet Haematology
    Edoxaban for venous thromboembolism in patients with cancer: results from a non-inferiority subgroup analysis of the Hokusai-VTE randomised, double-blind, double-dummy trial.
    Wilks, Sharon T., Yardley, etal.
    American Society of Clinical Oncology
    Weekly nab-Paclitaxel plus Gemcitabine (Gem) or Carboplatin (Carbo) versus Gem/Carbo as First Line Treatment for Metastatic Triple Negative (mTNBC) in a Phase II/III Trial (TnAcity).
    Wilks, Sharon T., Slamon, et al.
    American Society of Clinical Oncology
    Predictive Biomarkers of Everolimus efficacy in HER2+ Advanced Breast Cancer: Combined Exploratory Analysis from BOLERO-1 and BOLERO-3.
    Bersabe, Adrian REYES and Osswald, Michael B and Shumway, Nathan M
    ASCO Annual Meeting Proceedings
    Correlation of peripheral blood smear review and bone marrow biopsies for benign hematology Outpatient referrals.
    Greene JM, Schneble EJ, Martin J, Flores M, Berry, Trappey AF, Vreeland TJ, Hale DF, Sears AK, Clifton GT, von Hofe E, Ardavannis A, Shumway N, Ponniah S, Papamichail M, Perez S, Symanowski JT, Peoples GE, Mittendorf EA.
    ASCO Annual Meeting Proceedings
    Final pre-specified analysis of the phase II trial of the AE37+ GM-CSF vaccine in high risk breast cancer patients to prevent recurrence.
    James R. Berenson, Alan Cartmell, Roger M. Lyons, Wael A. Harb, Dimitrios Tzachanis, Agajanian, R, Boccia, R, Coleman, M, Moss, R, Rifkin, R, Schupp, M,  Dixon, S,  Ou, Y, Anderl, J, Berdeja, J.
    Blood
    Updated results from CHAMPION-1, a phase I/II study investigating weekly carfilzomib with dexamethasone for patients (Pts) with relapsed or refractory multiple myeloma (RRMM).
    Shah, J, Niesvizky, R, Stadtmauer, E, Rifkin, R, Berenson, J, Berdeja J, Sharman, J, Lyons, R, Klippel, Z, Wong, H, Chang, Y, Usmani, S.
    Blood
    Oprozomib, Pomalidomide, and Dexamethasone (OPomd) in Patients (Pts) with Relapsed and/or Refractory Multiple Myeloma (RRMM): Initial Results of a Phase 1b Study (NCT01999335).
    Manero, G, Berdeja, J, Komrokji, R, Essell, J, Lyons, R, Maris, M, DeZern, A, Sekeres, M, Roboz, G.
    Blood
    A Randomized, Placebo-Controlled, Phase II Study of Pracinostat in Combination with Azacitidine (AZA) in Patients with Previously Untreated Myelodysplastic Syndrome (MDS).
    Troung, P, Saltzman, M, Bessudo, A, Jawien, W, Lyons, R, Berenzon, D, Mena, R, Wingate-Pearse, N, Barriere, O, Beeson, H, Glidden, P, Choy, G, Verstovsek, S.
    Blood
    Final Results of Anagrelide Controlled-Release (GALE-401) Safety, Efficacy and Pharmacokinetics in Subjects with Myeloproliferative Neoplasms.
    Zoghi B, Shaughnessy P, Lyons RM, Helmer R 3rd, Bachier C, LeMaistre CF.
    Case Reports in Hematology
    Treatment of Acquired von Willebrand Syndrome and Prevention of Bleeding Postautologous Stem Cell Transplant during Severe Pancytopenia with IVIG.
    Wilks, S. & McIntyre, K
    Clinical Medicine Insights: Oncology
    Case Studies in the Management of Metastatic Breast Cancer with Eribulin.
    Verstovsek, S, Mesa, R, Gotlib, J, Levy, R, Gupta, V, DiPersio, J, Catalano, J, Deiniger, M, Miller, C, Silver, R, Talpaz, M, Winton, E, Harvey, J, Arcasoy, M, Hexner, E, Lyons, R, Raza, A, Vaddi, K, Sun, W, Peng E, Sandor, V Kantarjian, H.
    Haematologica
    Efficacy, Safety and Survival with Ruxolitinib in Patients with Myelofibrosis:  Results of a Median 3-year Follow-up of COMFORT-1.
    Cines DB, Gernsheimer T, Wasser J, Godeau B, Provan D, Lyons R, Altomare I, Wang X, Lopez A.
    International Journal of Hematology
    Integrated analysis of long-term safety in patients with chronic immune thrombocytopaenia (ITP) treated with the thrombopoietin (TPO) receptor agonist romiplostim.
    Djenic B, Walters JW, Hsu CH, Nodora JN, Martinez ME, Bouton ME, Mehta D, Komenaka IK
    San Antonio Breast Cancer Symposium
    The Benefit of Preoperative Chemotherapy in an Underinsured Hispanic Population with Poor Use of Screening Mammography
    Winton LM, Nodora JN, Hsu CH, Djenic B, Bouton ME, Aristizabal P, Ferguson EM, Weiss, BD, Komenaka IK
    Surgery
    Factors which Affect Surgical Management of Breast Cancer in an Underinsured, Safety Net Population
    Platzbecker U, Wong RS, Verma A, Abboud C, Araujo S, Chiou TJ, Feigert J, Yeh SP, Götze K, Gorin NC, Greenberg P, Kambhampati S, Kim YJ, Lee JH, Lyons R, Ruggeri M, Santini V, Cheng G, Jang JH, Chen CY, Johnson B, Bennett J, Mannino F, Kamel YM, Stone N, Dougherty S, Chan G, Giagounidis A.
    The Lancet Haematology
    Safety and tolerability of eltrombopag versus placebo for treatment of thrombocytopenia in patients with advanced myelodysplastic syndromes or acute myeloid leukaemia: a multicentre, randomised, placebo-controlled, double-blind, phase 1/2 trial.
    Andre, Fabrice, Sara Hurvitz, Angelica Fasolo, Ling-Ming Tseng, Guy Jerusalem, Sharon Wilks, Ruth O’Regan, Claudine Isaacs, Masakazu Toi, Howard Burris, Wei He, Douglas Robinson, Markus Riester Riester, Tetiana Taran, David Chen and Dennis Salmon
    Journal of Clinical Oncology
    Molecular Alterations and Everolimus  Efficacy in HER2-Overexpressing Metastatic Breast Cancers: Combined Exploratory Analysis from BOLERO-1 and BOLERO-3.
    Shumway, Nathan M and Dacus, Jennifer J and Lathrop, Kate I and Hernandez, Elizabeth P and Miller, Maria and Karnad, Anand B
    Journal of Graduate Medical Education
    Use of milestones and development of entrustable professional activities in 2 hematology/oncology training programs
    Shumway, Nathan M and Terrazzino, Sandra E and Jones, Christopher B
    Journal of Pain Management
    A randomized pilot study comparing olanzapine (Zyprexa) to aprepitant (Emend) for treatment of chemotherapy-induced nausea and vomiting
    Wilks, S. et al
    San Antonio Breast Cancer Symposium
    Phase I study of GR antagonist Mifepristone (M) in combination with Eribulin (E)in advanced solid tumors, with dose expansion in patients (pts)with GR-positive Triple Negative Breast Cancer (TNBC).
    Schnadig, Ian; Wilks, Sharon T.
    San Antonio Breast Cancer Symposium
    Phase 3 Comparison of APF530 versus Ondansetron, Each in a Guideline-Recommended 3-drug Regimen for Prevention of Chemotherapy Induced Nausea and Vomiting due to Anthracycline+ Cyclophosphamide (AC) Based Highly Emetogenic Chemotherapy (HEC) Regime.
    O’Shaughnessy, J. et al., Wilks Sharon T.
    Springer Plus Open Journal Volume 4
    Impact of Prior Anthracycline or Taxane on Eribulin Effectiveness as First-Line Treatment for Metastatic Breast Cancer: Results from Two Phase 2, Multicenter, Single-arm Studies.
    Wilks, Sharon T.
    The Breast
    Potential of Overcoming Resistance to HER2-Targeted Therapies through the PI3K/Akt/mTOR pathway.
    Lyons, R, Marek, B, Paley, C, Esposito, J, McNamara, K, Garbo, L, DiBella, N, Garcia-Manero, G.
    Blood
    Relationship Between Chelation and Clinical Outcomes in Lower-Risk Patients with Myelodysplastic Syndrome (MDS): Registry Analysis at 5 Years.
    Mesa, R, Vannucchi, A, Yacoub, A, Zachee, P, Garg, M, Lyons, R, Chedid, S, Koschmieder, S, Rinaldi, C, Byrne, J, Hasan, Y, Passamonti, F, Verstovsek, S, Hunter, D, Jones, M, He, S, Morozov, A, Martino, B.
    Blood
    The Efficacy and Safety of Continued Hydroxyurea Therapy Versus Switching to Ruxolitinib in Patients with Polycythemia Vera: A Randomized, Double-Blind, Double-Dummy, Symptom Study (RELIEF).
    Brano Djenic, Daniel Duick, James O. Newell, Michael J. Demeure
    International Journal of Surgery
    Solitary Liver Metastasis from Follicular Variant Papillary Thyroid Carcinoma: A Case Report and Literature Review
    Davidson BL, Verheijen S, Lensing AW, Gebel M, Brighton TA, Lyons RM, Rehm J, Prins MH.
    JAMA Internal Medicine
    Bleeding risk of patients with acute venous thromboembolism taking nonsteroidal anti-inflammatory drugs or aspirin.
    Klemens AE, Olsen-Deeter L, Hsu CH, Bouton ME, Djenic B, Winton LM, Komenaka IK
    The American Journal of Surgery
    Factors which Affect the Use of Lumpectomy and Mastectomy in an Underinsured, Safety Net Hospital Population
    Prins, M,  Lensing, A, Brighton, T, Lyons, R, Rehm, J, Trajanovic, M,  Davidson, B,  Beyer-Westendorf, J, Pap, A, Berkowitz, S, Cohen, A, Kovacs, M, Wells, P,  Prandoni, P.
    The Lancet Haematology
    Oral Rivaroxaban Versus Enoxaparin with Vitamin K Antagonist for the Treatment of Symptomatic Venous, Thromboembolism in Patients with Cancer (EINSTEIN-DVT and EINSTEIN-PE): a Pooled Subgroup Analysis of Two Randomised Controlled Trials.
    Shumway NM, Lathrop KI, Dacus JJ, Miller M, Hernandez EP, Karnad AB
    Accreditation Council of Graduate Medical Education
    Use Of Milestones And Development Of Entrustable Professional Activities (EPAs) In Hematology/Oncology (HO) Training Programs -- A Proactive And Practical Approach to a New Evaluation System.
    Shumway, Nathan M and Dacus, Jennifer Jill and Lathrop, Kate Ida and Hernandez, Elizabeth P and Miller, Maria and Karnad, Anand B
    ASCO Annual Meeting Proceedings
    Informed consent training for medical oncology fellows: Checklist-based simulation exercise.
    Dacus, Jennifer Jill and Shumway, Nathan M and Lathrop, Kate Ida and Hernandez, Elizabeth P and Miller, Maria and Karnad, Anand B
    ASCO Annual Meeting Proceedings
    Chemotherapy infusion reaction training for medical oncology fellows: A checklist-based simulation exercise.
    Mittendorf EA, Schneble EJ, Perez S, Symanowski JT, Patil R, Vreeland TJ, Berry JS, Trappey AF, Hale DF, Sears AK, Clifton GT, von Hofe E, Ardavannis A, Ponniah S, Shumway N, Papamichail M, Peoples GE. 
    ASCO Annual Meeting Proceedings
    Primary analysis of the prospective, randomized, phase II trial of GP2+ GM-CSF vaccine versus GM-CSF alone administered in the adjuvant setting to high-risk breast cancer patients
    Erika J Schneble, Sonia A. Perez, John S. Berry, Alfred F Trappey, Tim Vreeland, Diane F. Hale, Alan K. Sears, Guy T. Clifton, Eric von Hofe, Alexandros Ardavanis, Nathan M. Shumway, Sathibalan Ponniah, Michael Papamichail, George Earl Peoples, Elizabeth Ann Mittendorf
    ASCO Annual Meeting Proceedings
    Comparison of recurrent and nonrecurrent breast cancer patients undergoing AE37 peptide vaccine therapy.
    Elizabeth Ann Mittendorf, Erika J Schneble, Sonia A. Perez, James T Symanowski, Ritesh Patil, Timothy J. Vreeland, John S. Berry, Alfred F Trappey, Guy T. Clifton, Eric von Hofe, Alexandros Ardavanis, Sathibalan Ponniah, Nathan M. Shumway, Michael Papamichail, George Earl Peoples
    ASCO Annual Meeting Proceedings
    Primary analysis of the prospective, randomized, single-blinded phase II trial of AE37 vaccine versus GM-CSF alone administered in the adjuvant setting to high-risk breast cancer patients.
    Bersabe, Adrian R and Osswald, Michael and Shumway, Nathan M
    Blood
    Peripheral Blood Smear Utilization within a Military Hematology/Oncology Fellowship Program
    Wilks, Sharon et al
    Clinical Breast Cancer
    Phase 2, Multicenter, Single-Arm Study of Eribulin Mesylate + Trastuzumab as First Line Therapy for Locally Recurrent or Metastatic HER2 Positive Breast Cancer.

    Roger M. Lyons

    International Blood Research & Reviews
    Iron Overload, Chelation Therapy and Survival in Lower-risk Myelodysplastic Syndromes: State of Evidence

    Download full publication here.

    Graham LJ, Shupe MP, Schneble EJ, Flynt FL, clemenshaw MN, Kirkpatrick AD, Gallagher C, Nissan A, Henry L, Stojadinovic A, Peoples GE, Shumway NM
    Journal of Cancer
    Current approaches and challenges in monitoring treatment responses in breast cancer
    Schneble EJ, Graham LJ, Shupe MP, Flynt FL, Banks KP, Kirkpatrick AD, Nissan A, Henry L, Stojadinovic A, Shumway NM, Avital I, Peoples GE, Setlik RF. 
    Journal of Cancer
    Current approaches and challenges in early detection of breast cancer recurrence
    Shupe, Matthew P and Graham, Lindsey J and Schneble, Erika J and Flynt, Frederick L and Clemenshaw, Michael N and Kirkpatrick, Aaron D and Stojadinovic, Alexander and Peoples, George E and Shumway, Nathan M
    Journal of Cancer
    Future directions for monitoring treatment responses in breast cancer
    Schneble EJ, Graham LJ, Shupe MP, Flynt FL, Banks KP, Kirkpatrick AD, Nissan A, Henry L, Stojadinovic A, Shumway NM, Avital I, Peoples GE, Setlik RF.
    Journal of Cancer
    Future directions for the early detection of recurrent breast cancer
    Wilks, Sharon T., Andre, Fabrice, etal
    The Lancet Oncology
    Everolimus for Women with Trastuzumab Resistant, HER2 Positive, Advanced Breast Cancer (BOLERO-3): A Randomized, Double Blind, Placebo Controlled Phase III Trial.

    Roger Lyons
    Uwe Platzbecker, Raymond SM Wong, Amit Verma, Camille Abboud, Sergio Araujo, Tzeon-Jye Chiou, John Feigert, Su-Peng Yeh, Katharina Götze, Norbert-Claude Gorin, Peter Greenberg, Suman Kambhampati, Yoo-Jin Kim, Je-Hwan Lee, Marco Ruggeri, Valeria Santini, Gregory Cheng, Jun Ho Jang, Chien-Yuan Chen, Souria Dougherty, Frank Mannino, Yasser Mostafa Kamel, Geoffrey Chan, Michael Arning, Nicole Stone, Aristoteles Giagounidis

    18th Congress of the European Hematology Association
    Placebo-controlled, Randomized, Phase I/II Trial of the Thrombopoeitin Receptor Agonist Eltrombopag in Thrombocytopenic Patients with Advanced Myelodysplastic Syndromes or Acute Myeloid Leukemia

    Download full publication here.

    Vreeland, TJ and Berry, JS and Trappey, AF and Hale, D and Clifton, GT and Sears, A and Shumway, NM and Holmes, JP and Ponniah, S and Mittendorf, EA and others
    Annals Of Surgical Oncology
    Use of an Attenuated Version of a Strongly Immunogenic, Peptide-based Vaccine to Enhance an Anti-cancer Immune Response against Folate Receptor-alpha (FR alpha)
    Patil, Ritesh and Clifton, Guy T and Litton, Jennifer Keating and Shumway, Nathan M and Vreeland, Timothy J and Berry, John S and Trappey, Alfred F and Ponniah, Sathibalan and Peoples, George Earl and Mittendorf, Elizabeth Ann
    ASCO Annual Meeting Proceedings
    Safety and efficacy of the HER2-derived GP2 peptide vaccine in combination with trastuzumab for breast cancer patients in the adjuvant setting.
    Trappey, Alfred F and Berry, John S and Vreeland, Timothy J and Hale, Diane F and Sears, Alan K and Ponniah, Sathibalan and Perez, Sonia A and Clifton, Guy T and Papamichail, Michael and Shumway, Nathan M and others
    ASCO Annual Meeting Proceedings
    Risk factors for development of delayed urticarial reactions in the phase II trial of HER2 peptide vaccines plus GM-CSF versus GM-CSF alone in high-risk breast cancer patients to prevent recurrence.
    Lyons, R, Marek, B, Paley, C, Esposito, J, McNamara, K, Garbo, L, DiBella, N, Garcia-Manero, G.
    Blood
    48-Month Update on Survival and AML Transformation in a 600-Patient Registry of Lower-Risk MDS Patients.
    Platzbecker, U, Wong, R, Verma, A, Abboud, C, Araujo, S, Chiou, T, Feigert, J, Yeh, S, Gotze, K, Gorin, N, Greenberg, P, Kambhampati, S, Kim, Y, Lee, J, Lyons, R, Ruggeri, M, Santini, V, Cheng, G, Jang, Jun, Chen, C, Dougherty, S, Mannino, F, Kamel, Y, Chan, G, Stone, N, Giagounidis, A.
    Blood
    Randomized, Placebo-Controlled, Phase I/II Trial of the Thrombopoietin Receptor (TPO-R) Agonist Eltrombopag in Thrombocytopenic Patients with Advanced Myelodysplastic Syndromes or Acute Myeloid Leukemia—A Subgroup Analysis of Patients Receiving Concomitant Anticancer Therapy.
    Raskob, G, Buller, H, Angchaisuksiri, P, Oh, D, Boda, Z, Lyons, R, Weitz, J, Zhang, G, Lanz, H, Mercuri, M.
    Blood
    Edoxaban for Long-term Treatment of Venous Thromboembolism in Cancer Patients.
    Verstovsek, S, Mesa, R, Gotlib, J, Levy, R, Gupta, V, Dipersio, J, Catalano, J, Deininger, M, Miller, C, Silver, R, Talpaz, M, Winton, E, Harvey, J, Arcasoy, M, Hexner, E, Lyons, R, Paquette, R, Raza, A, Vaddi, K, Sun, W, Peng, W, Sandor, V, Kantarjian, H.
    Blood
    Long-term Outcomes of Ruxolitinib Therapy in Patients with Myelofibrosis:  3-year Update from COMFORT-1.
    Shaughnessy, P, Kelley, A, Tremper, R, Tinker, J, Bachier, C, Holahan, J, Lyons, R, LeMaistre, C.
    Blood
    The VIP (Very Immunocompromised Patient) Protocol:  Improved Access to Care and Time to Antibiotics.
    Gopal, A, Kahl, B, De Vos, S, Wagner-Johnston, N, Schuster, S, Blum, K, Jurczak, W, Flinn, I, Flowers, C, Martin, P, Viardot, A, Goy, A, Davies, A, Zinzani, P, Dreyling, M, Holes, L., Li, D, Dansey, R, Godfrey, W, Salles, G.
    Blood
    Mature Response Data From a Phase 2 Study of PI3K-Delta Inhibitor Idelalisib In Patients With Double (Rituximab and Alkylating Agent)-Refractory Indolent B-Cell Non-Hodgkin Lymphoma (iNHL).

    Roger M. Lyons
    Srdan Verstovsek, Ruben A. Mesa, Jason Gotlib, Richard S. Levy, Vikas Gupta, John F. DiPersio, John V. Catalano, Michael Deininger, Carole Miller, Richard T. Silver, Moshe Talpaz,11 Elliott F. Winton, Jimmie H. Harvey Jr, Murat O. Arcasoy, Elizabeth Hexner, Ronald Paquette, Azra Raza, Kris Vaddi, Susan Erickson-Viitanen, William Sun, Victor Sandor, Hagop M. Kantarjian

    British Journal of Haematology
    The Clinical Benefit of Ruxolitinib Across Patient Subgroups: Analysis of a Placebo-controlled, Phase III Study in Patients with Myelofibrosis

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    Roger M Lyons
    DJ Kuter, JB Bussel, A Newland, RI Baker, J Wasser, JF Viallard, G Macik, M Rummel, K Nie, S Jun.

    British Journal of Haematology
    Long-Term Treatment with Romiplostim in Patients with Chronic Immune Thrombocytopenia (ITP): Safety and Efficacy
    Trappey, AF and Berry, JS and Vreeland, TJ and Guy, CT and Diane, HF and Alan, SK and Erika, SJ and Ferrise, L and Shumway, NM and Papamichail, M and others
    Cancer Research
    Abstract P4-13-05: HLA-A2 is not a prognostic indicator in breast cancer: Implications for cancer vaccine trials
    Berry, John S and Trappey, Alfred F and Vreeland, Timothy J and Hale, Diane F and Clifton, Guy T and Sears, Alan K and Shumway, Nathan M and Ponniah, Sathibalan and Holmes, Jarrod P and Ioannides, Constantin and others
    Cancer Research
    Use of an attenuated version of a strongly immunogenic, peptide-based vaccine to enhance an anti-cancer immune response against folate receptor-alpha.
    Vreeland, TJ and John, BS and Trappey, AF and Schneble, EJ and Hale, DF and Clifton, GT and Shumway, NM and Perez, SA and Papamichail, M and Ponniah, S and others
    Cancer Research
    Breast cancer patients with HER2 low-expression: An under-recognized group at significant risk for recurrence
    Berry, JS and Trappey, AF and Vreeland, TJ and Schneble, EJ and Clifton, GT and Hale, DF and Sears, AK and Ponniah, S and Shumway, NM and Mittendorf, EA and others
    Cancer Research
    Preliminary results for the phase 1 trial of a dual HER2 peptide cancer vaccine in breast and ovarian cancer patients

    Roger M. Lyons
    Deirdra R. Terrell, PhD, James N. George, MD, James B. Bussel, MD, MD, FACP, Vinod Pullarkat, MD, Robert L. Redner, MD, Dominik Selleslag, MD, Kun Nie, PhD, Paul Woodard, MD

    Community Oncology
    Self-Administration of Romiplostim in Patients with Chronic Immune Thrombocytopenia (ITP)

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    Roger M. Lyons
    Andres Siulnik, Vikas Gupta, Mahmudul Khan, John F. DiPersio, Mari McQuitty, John V. Catalano, Deborah S. Hunter, Laurent Knoops, Michael Deininger, Francisco Cervantes, Carole Miller, Alessandro M. Vannucchi, Richard T. Silver, Tiziano Barbui, Moshe Talpaz, Giovanni Barosi, Elliott F. Winton, Estella Mendeson, Jimmie H. Harvey, Jr, Murat O. Arcasoy, Elizabeth Hexner, Richard Levy, Ronald Paquette, Azra Raza, William Sun, Victor Sandor, Hagop M. Kantarjian, Claire Harrison

    Haematologica
    Comparison of Placebo and Best Available Therapy for the Treatment of Myelofibrosis in the Phase 3 COMFORT Studies

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    Roger M. Lyons
    Richard S. Levy, Srdan Verstovsek, Ruben A. Mesa, Jason Gotlib, Vikas Gupta, John F. DiPersio, John V. Catalano, Michael W.N. Deininger, Carole B. Miller, Richard T. Silver, Moshe Talpaz, Elliott F. Winton, Jimmie H. Harvey, Murat O. Arcasoy, Elizabeth O. Hexner, Roger M. Lyons, Ronald Paquette, Azra Raza, Kris Vaddi, Susan Erickson-Viitanen, William Sun, Victor Sandor, and Hagop M. Kantarjian

    Haematologica
    Efficacy, Safety and Survival with Ruxolitinib Treatment in Patients with Myelofibrosis: Results of a Median 2-year Follow-up of COMFORT-1

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    Schneble, Erika J and Berry, John S and Trappey, Alfred F and Vreeland, Timothy J and Hale, Diane F and Sears, Alan K and Clifton, Guy T and Ponniah, Sathibalan and Shumway, Nathan M and Mittendorf, Elizabeth A and others
    Journal for Immunotherapy of Cancer
    Vaccine-specific T-cell proliferation in response to a dual peptide cancer vaccine in breast and ovarian cancer patients.
    Talpaz, M, Paquette, R, Afrin, L, Hamburg, S, Prchal, J, Jamieson, K, Terebelo, H, Ortega, G, Lyons, R, Tiu, R, Winton, E, Natrajan, K, Odenike, O, Claston, D, Peng, W, O’Neill, P, Erickson-Vitanen, S, Leopold, L, Sandor, V, Levy, R, Kantarjian, H, Verstovsek, S.
    Journal of Hematology & Oncology
    Interim Analysis of Safety and Efficacy of Ruxolitinib in Patients with Myelofibrosis and Low Platelet Counts.
    Wilks, Sharon, et al.
    San Antonio Breast Cancer Symposium
    Phase 2, Multicenter, Single-Arm Study of Eribulin Mesylate + Trastuzumab as First Line Therapy for Locally Recurrent or Metastatic HER2 Positive Breast Cancer.
    Hokusai-VTE Investigators, Buller, H, Decousus, H, Grosso, M, Mercuri, M, hiddeldorp, S, Prins, M, Roskob G, Schellong, S, Schwocho, L, Segars, A, Shi, M, Verhamme, P, Wells, P.
    The New England Journal of Medicine
    Edoxaban Versus Warfarin for the Treatment of Symptomatic Venous Thromboembolism.

    Joyce O’Shaughnessy, MD
    Linda Vahdat, MD, Lee Schwartzberg, MD, Sharon Wilks, MD, FACP, Jessicca Rege, PhD, Wenquan Wang, PhD, David Cox, PhD

    35th Annual San Antonio Breast Cancer Symposium
    Eribulin Mesylate with Trastuzumab as First-Line Therapy for Locally Recurrent or Metastatic Human Epidermal Growth Factor Receptor Two (HER2)-Positive Breast Cancer: Preliminary Results from a Phase 2, Multicenter, Single-Arm Study

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    Roger M. Lyons, MD
    Srdan Verstovsek, MD, PhD, Ruben A. Mesa, Jason Gotlib, Richard S. Levy, MD, Vikas Gupta, MD, FRCP, FRCPath, John F. DiPersio, MD, PhD, John V. Catalano, MD, Michael W.N. Deininger, MD, PhD, Carole B. Miller, MD, Richard T. Silver, MD, Moshe Talpaz, MD, Elliott F. Winton, MD, Jimmie H. Harvey, Jr., MD, Murat O. Arcasoy, MD, Elizabeth O. Hexner, MD, Ronald Paquette, MD, PhD, Azra Raza, MD, Kris Vaddi, PhD, Susan Erickson-Viitanen, PhD, William Sun, PhD, Victor A. Sandor, MD, CM, Hagop M. Kantarjian, MD

    54th Annual Meeting of the American Society of Hematology
    Long-Term Outcome of Ruxolitinib Treatment in Patients with Myelofibrosis: Durable Reductions in Spleen Volume, Improvements in Quality of Life, and Overall Survival Advantage in COMFORT-1

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    Hale DF, Vreeland TJ, Dabney RS, Clifton GT, Sears AK, Pappou E, Anastosopoulou E, Ardavanis A, Ponniah S, Papamichail M, Perez S, Shumway N, Peoples GE, Mittendorf E.
    American Association for Cancer Research AACR
    Abstract LB-218: Immune response assessment in a phase II trial of AE37 HER2 peptide vaccine
    Randall C, Taboada C, Djenic B, Martinez N, Vizuete J, Havranek R
    American Journal of Gastroenterology
    Nitazoxanide Is Efficacious in the Treatment of Small Intestinal Bacterial Overgrowth

    Roger M Lyons

    American Journal of Medicine
    Myelodysplastic Syndromes: Therapy and Outlook

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    Shumway, Nathan M and Struble, Erika J
    ASCO Annual Meeting Proceedings
    Prospective survey study regarding the implementation of new communication skills curriculum for medical oncology trainees.
    Diane F Hale, Sonia A. Perez, Timothy J Vreeland, Alfred F Trappey, Raetasha Sheavette Dabney, John S. Berry, Alexandros Ardavanis, Alan K. Sears, Michael Papamichail, Guy T. Clifton, Efi Pappou, Ritesh Patil, Eleftheria Anastasopoulou, Sathibalan Ponniah, Nathan M. Shumway, George Earl Peoples and Elizabeth Ann Mittendorf 
    ASCO Annual Meeting Proceedings
    An assessment of disease features and immune response in breast cancer patients that did not recur after receiving HER2 peptide, AE37 vaccine in a randomized phase II trial.
    Mittendorf, Elizabeth Ann and Perez, Sonia A and Hale, Diane F and Vreeland, Timothy J and Sears, Alan K and Clifton, Guy T and Ardavanis, Alexandros and Shumway, Nathan M and Murray, James L and Ponniah, Sathibalan and others
    ASCO Annual Meeting Proceedings
    Early efficacy analysis of the AE37 vaccine in patients with HER2 low-expressing and triple-negative breast cancer.
    Dabney, Raetasha Sheavette and Hale, Diane F and Vreeland, Timothy J and Clifton, Guy T and Sears, Alan K and Patil, Ritesh and Ponniah, Sathibalan and Shumway, Nathan M and Peoples, George Earl and Mittendorf, Elizabeth Ann
    ASCO Annual Meeting Proceedings
    Safety and long-term maintenance of anti-HER2 immunity following booster inoculations of the E75 breast cancer vaccine.
    Vreeland TJ, Hale DF, Sears AK, Clifton GT, Pappou E, Dabney RS, Ardavanis A, Patil R, Ponniah S, Anastasopoulou E, Perez SA, Papamichail M, Shumway NM, Peoples GE, Mittendorf EA.
    ASCO Annual Meeting Proceedings
    From bench to bedside: The use of the li-Key technology to improve helper peptides for clinical use in cancer vaccines.
    Hale, DF and Vreeland, TJ and Perez, SA and Berry, JS and Ardavanis, A and Trappey, AF and Tzonis, P and Sears, AK and Clifton, GT and Shumway, NM and others
    Cancer Research
    The combination of trastuzumab and HER2-directed peptide vaccines is safe in HER2-expressing breast cancer patients
    Vreeland, Timothy J and Dabney, Raetasha S and Hale, Diane F and Sears, Alan K and Clifton, Guy T and Zacharia, Athina and Jama, Yusuf and Chiplis, Anna and Mursal, Mohamed and Shumway, Nathan M and others
    Cancer Research
    Immune reconstitution after chemotherapy correlates with increased in vitro immune response in breast cancer patients undergoing peptide vaccine therapy
    Diane F. Hale, Timothy J. Vreeland, Raetasha S. Dabney, G Travis Clifton, Alan K. Sears, Efi Pappou, Eleftheria Anastasopoulou, Alexandros Ardavanis, Sathibalan Ponniah, Michael Papamichail, Sonia Perez, Nathan Shumway, George E. Peoples, Elizabeth Mittendorf
    Cancer Research
    Abstract LB-218: Immune response assessment in a phase II trial of AE37 HER2 peptide vaccine
    JM Greene, EJ Schneble, S Perez, JL Murray, JS Berry, AF Trappey, DF Hale, TJ Vreeland, GT Clifton, A Ardavanis, JK Litton, NM Shumway, M Papamichail, GE Peoples, EA Mittendorf 
    Cancer Research
    Abstract P2-11-01: Final pre-specified analysis of the phase II trial of the GP2+ GM-CSF peptide vaccine in high risk breast cancer patients to prevent recurrence
    Hale, Diane F and Clifton, G Travis and Sears, Alan K and Vreeland, Timothy J and Shumway, Nathan and Peoples, George E and Mittendorf, Elizabeth A
    Expert Review of Vaccines
    Cancer vaccines: should we be targeting patients with less aggressive disease?

    Roger M. Lyons
    Moshe Talpaz, Solomon I. Hamburg, Katarzyna Jamieson, Howard R. Terebelo, Lawrence Afrin, Elliott F. Winton, Michael A. Scola, Jimmie Huling Harvey, Chris E. Holmes, Gregory L. Ortega, Josef T. Prchal, Richard T. Silver, Maria R. Baer, Susan Kay Erickson-Viitanen, Peter O'Neill, Wei Peng, Lance Leopold, Hagop Kantarjian, Srdan Verstovsek

    Journal of Clinical Oncology
    Preliminary Safety and Efficacy of Ruxolitinib in Patients with Primary and Secondary Myelofibrosis with Platelet Counts of 50-100x10^9L

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    Roger M. Lyons
    Eunice S Wang, Roger M Lyons, Richard A Larson, Sunil Gandhi, Delong Liu, Carmen Matei, Bart Scott, Kuolung Hu, Allen S Yang

    Journal of Hematology & Oncology
    A Randomized, Double-blind, Placebo-controlled Phase 2 Study Evaluating the Efficacy and Safety of Romiplostim Treatment of Patients with Low or Intermediate-1 Risk Myelodysplastic Syndrome Receiving Lenalidomide

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    Roger M Lyons
    Azra Raza1, Naomi Galili1, Deborah Mulford, Scott E Smith, Gail L Brown, David P Steensma, Ralph Boccia, Mikkael A Sekeres, Guillermo Garcia-Manero, Ruben A Mesa

    Journal of Hematology & Oncology
    Phase 1 Dose-ranging Study of Ezatiostat Hydrochloride in Combination with Lenalidomide in Patients with Non-deletion (5q) Low to Intermediate-1 Risk Myelodysplastic Syndrome (MDS)

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    Berry, JS and Vreeland, TJ and Trappey, AF and Hale, DF and Clifton, GT and Sears, AK and Patil, R and Shumway, NM and Holmes, JP and McCall, S and others
    Journal of Immunotherapy
    Trends in Circulating Tumor Cells (CTCS) in Multiple Adjuvant (ADJ) Trials of HER2-Specific Peptide Vaccines (PV) in Breast Cancer (BRCA) PTS
    Claxton, D, Erba, H, Faderi, S, Arellano, M, Lyons, R, Kovacsovics, R, Gabrilove, J, Huebner, D, Gandhi, P, Kantarjian, H.
    Leukemia and Lymphoma
    Outpatient Consolidation Treatment with Clofarabine in a Phase 2 Study of Older Adult Patients with Previously Untreated Acute Myelogenous Leukemia (AML).

    Roger M Lyons
    Srdan Verstovsek, M.D., Ph.D., Ruben A. Mesa, M.D., Jason Gotlib, M.D., Richard S. Levy, M.D., Vikas Gupta, M.D., John F. DiPersio, M.D., Ph.D., John V. Catalano, M.D., Michael Deininger, M.D., Ph.D., Carole Miller, M.D., Richard T. Silver, M.D., Moshe Talpaz, M.D., Elliott F. Winton, M.D., Jimmie H. Harvey, Jr., M.D., Murat O. Arcasoy, M.D., Elizabeth Hexner, M.D., Ronald Paquette, M.D., Azra Raza, M.D., Kris Vaddi, Ph.D., Susan Erickson-Viitanen, Ph.D., Iphigenia L. Koumenis, M.S., William Sun, Ph.D., Victor Sandor, M.D., and Hagop M. Kantarjian, M.D.

    New England Journal of Medicine
    A Double-Blind, Placebo-Controlled Trial of Ruxolitinib for Myelofibrosis

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    Verstovsek, S, Mesa, R, Gotlib, J, Levy, R, Gupta, V, DiPersio, J, Catalano, J, Deininger, M, Miller, C, Silver, R, Talpaz, M, Winton, E, Harvey, J, Arcasoy, M, Hexner, E, Lyons, R, Paquette, R, Raza, A, Vaddi, K, Erickson-Viitanen, S, Koumenis, I, Sun, W, Sandor, V, Kantarjian, H.
    The New England Journal of Medicine
    A Double-Blind Placebo-Controlled Trial of Ruxolitinib for Myelofibrosis.
    Haney B, Shumway NM, Peoples GE
    Advances in the Management of Triple Negative Breast Cancer
    Advances in the Management of Triple Negative Breast Cancer Ch.9: Targeted therapies: other agents in clinical trials
    Sears, AK and Clifton, GT and Patil, R and Shumway, NM and Carmichael, MG and Van Echo, DC and Holmes, JP and Ponniah, S and Mittendorf, EA and Peoples, GE
    ASCO Annual Meeting Proceedings
    Sequential administration of trastuzumab and a CD8 T-cell-eliciting HER2/neu peptide vaccine in patients with breast cancer compared to trastuzumab alone.
    Clifton, GT and Sears, AK and Patil, R and Shumway, NM and Carmichael, MG and Van Echo, DC and Holmes, JP and McCall, S and Merrill, GA and Ponniah, S and others
    ASCO Annual Meeting Proceedings
    Monitoring of circulating tumor cell trends in a prospective, randomized, placebo-controlled HER2/neu peptide vaccine trial.

    Roger M. Lyons, MD
    David J. Kuter, MD, DPhil, James B. Bussel, MD, Adrian Newland, FRCP, Jeffrey S. Wasser, MD, James N. George, MD, Gail Macik, MD, Kun Nie, Susie Jun

    Blood
    Long-Term Efficacy and Safety of Romiplostim Treatment of Adult Patients with Chronic Immune Thrombocytopenia (ITP): Final Report from an Open-Label Extension Study

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    Sears, Alan K and Perez, Sonia A and Clifton, Guy T and Benavides, Linda C and Gates, Jeremy D and Clive, Kevin S and Holmes, Jarrod P and Shumway, Nathan M and Van Echo, David C and Carmichael, Mark G and others
    Expert Opinion on Biological Therapy
    AE37: a novel T-cell-eliciting vaccine for breast cancer

    Roger M Lyons
    Craig Reynolds, Nicholas Di Bella, William Hyman, Donald A. Richards, Gerald J. Robbins, Mark Vellek, Kristi A. Boehm, Feng Zhan & Lina Asmar

    Investigational New Drugs
    A Phase III Trial of Fludarabine, Cyclophosphamide, and Rituximab vs. Pentostatin, Cyclophosphamide, and Rituximab in B-Cell Chronic Lymphocytic Leukemia

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    Roger M. Lyons
    Sharon T Wilks, Shelby Young, Gail L Brown

    Journal of Hematology & Oncology
    Oral Ezatiostat HCl (Telintra, TLK199) and Idiopathic Chronic Neutropenia (ICN): A Case Report of Complete Response of a Patient with G-CSF Resistant ICN Following Treatment with Ezatiostat, a Glutathionie S-transferase P1-1 (GSTP1-1) Inhibitor

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    Lyons, R, Wilks, S, Young, S, Brown, G. 
    Journal of Hematology & Oncology
    Oral Ezatiostat HCl (Telintra, TLK 199) and Idiopathic Chronic Neutropenia (ICN):  A Case Report of Complete Response of a Patient with G-CSF Resistant ICN Following Treatment with Ezatiostat, a Glutathione S-transferase P1-1 (GSTP1-1) Inhibitor.

    Roger M Lyons
    David Claxton, Harry P. Erba, Stefan Faderl, Martha Arellano, Tibor Kovacsovics, Janice Gabrilove, Dirk Huebner, Pritesh J. Gandhi, Hagop Kantarjian

    Leukemia and Lymphoma
    Outpatient Consolidation Treatment with Clofarabine in a Phase 2 Study of Older Adult Patients with Previously Untreated Acute Myelogenous Leukemia (AML)

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    R.M. Lyons
    P. Fenaux, H. Kantarjian, R.A. Larson, M.A. Sekeres, P.S. Becker, P. Muus, C. Jia, A.S. Yang

    Leukemia Research
    Update of an Open-Label Extension Study Evaluating the Long-Term Safety & Efficacy of Romiplostim in Thrombocytopenic Patients with Myelodysplastic Syndromes

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    Roger M. Lyons
    Nicholas Di Bella, Raymond Taetle, Kathryn Kolibaba, Thomas Boyd, Robert Raju, David Barrera, Ernest W. Cochran Jr, Philip Y. Dien, Peter J. Schlegel, Svetislava J. Vukelja, Julie Boston, Kristi A. Boehm, Yunfei Wang, Lina Asmar

    Blood
    Results of a Phase II Study of Bortezomib in Patients with Relapsed or Refractory Indolent Lymphoma

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    Roger M. Lyons
    Hagop Kantarjian, Pierre Fenaux, Mikkael A. Sekeres, Pamela S. Becker, Adam Boruchov, David Bowen, Eva Hellstrom-Lindberg, Richard A. Larson, Petra Muus, Jamile Shammo, Robert Siegel, Kuolung Hu, Janet Franklin, Dietmar P. Berger

    Journal of Clinical Oncology
    Safety and Efficacy of Romiplostim in Patient with Lower-risk Myelodysplastic Syndrome (MDS) and Thrombocytopenia

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    Roger M. Lyons
    Hagop M. Kantarjian, Harry P. Erba, David Claxton, Martha Arellano, Tibor Kovascovics, Janice Gabrilove, Michael Craig, Dan Douer, Michael Maris, Stephen Petersdorf, Paul J. Shami, Andrew M. Yeager, Stephen Eckert, Rekha Abichandani, and Stefan Faderl

    Journal of Clinical Oncology
    Phase II Study of Clofarabine Monotherapy in Previously Untreated Older Adults with Acute Myeloid Leukemia and Unfavorable Prognostic Factors

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    Shumway, NM and Terrazzino, SE and Jones, CB
    ASCO Annual Meeting Proceedings
    A randomized pilot study comparing aprepitant to olanzapine for treatment of chemotherapy-induced nausea and vomiting
    Shumway, Nathan M and Ibrahim, Nuhad and Ponniah, Sathibalan and Peoples, George E and Murray, James L
    BioDrugs
    Therapeutic Breast Cancer Vaccines

    Roger M. Lyons
    James B. Bussel, David J. Kuter, Vinod Pullarkat, Matthew Guo, Janet L. Nichol

    Blood
    Safety and Efficacy of Long-Term Treatment with Romiplostim in Thrombocytopenic Patients with ITP

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    Roger M. Lyons
    JN George, SD Mathias, RS Go RS, M Guo, DH Henry, RL Redner, L Rice, MR Schipperus

    British Journal of Haematology
    Improved Quality of Life for Romiplostim-Treated Patients with Chronic Immune Thormbocytopenic Purpura: Results from Two Randomized, Placebo-Controlled Trials

    Roger M. Lyons, M.D., F.A.C.P.
    Jamile M. Shammo, M.D., F.A.S.C.P., Lewis R. Silverman, M.D., Bart L. Scott, M.D.

    Clinical Advances in Hematology & Oncology
    Treatment Selection for Myelodysplastic Syndrome Patients in a Community Setting 

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    Lyons, R.  Clinical Roundtable Monograph.
    Clinical Advances in Hematology & Oncology
    Choosing the Appropriate Therapy for Lower-risk MDS in the Community Setting.

    Roger M. Lyons
    Thomas M. Cosgriff, Sanjiv S. Modi, Robert H. Gersh, John D. Hainsworth, Allen L. Cohn, Heidi J. McIntyre, Indra J. Fernando, Jay T. Backstrom, C.L. Beach

    Journal of Clinical Oncology
    Hematologic Response to Three Alternative Dosing Schedules of Azacitidine in Patients with Myelodysplastic Syndromes

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    Roger M. Lyons, MD
    James B. Bussel, David J. Kuter, Vinod Pullarkat, Matthew Guo, Janet L. Nichol

    Blood
    Safety and Efficacy of Long-Term Treatment with Romiplostim in Thrombocytopenic Patients with ITP

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    Roger M. Lyons
    Janice Gabrilove, Ronald Paquette, Chaudhry Mushtaq, Mikkael A. Sekeres, Dianne Tomita, Lyndah Dreiling

    British Journal of Haematology
    Phase 2, Single-arm, Trial to Evaluate the Effectiveness of Darbopoetin alfa for Correcting Anaemia in Patients with Myelodysplastic Syndromes

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    Roger M. Lyons, MD, FACP
    Richard Stone, MD, Mikkael Sekeres, MD, MS, Guillermo Garcia-Manero, MD

    Clinical Advances in Hematology & Oncology
    Recent Advances in Low- and Intermediate-1--Risk Myelodysplastic Syndrome: Developing a Consensus for Optimal Therapy

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    Stone, R, Sekeres, M, Garcia-Manero, G, Lyons, R.
    Clinical Advances in Hematology & Oncology
    Recent Advances in Low- and Intermediate-1—Risk Myelodysplastic Syndrome:  Developing a Consensus for Optimal Therapy.
    Weiss, Brendan M and Shumway, Nathan M and Howard, Robin S and Ketchum, Lloyd K and Reid, Thomas J
    Journal of Thrombosis and Thrombolysis
    Optical density values correlate with the clinical probability of heparin induced thrombocytopenia

    Roger M. Lyons
    David J Kuter, James B Bussel, Vinod Pullarkat, Terry B Gernsheimer, Francis M Senecal, Louis M Aledort, James N George, Craig M Kessler, Miguel A Sanz, Howard A Liebman, Frank T Slovick, J Th M de Wolf, Emmanuelle Bourgeois, Troy H Guthrie Jr, Adrian Newland, Jeff rey S Wasser, Solomon I Hamburg, Carlos Grande, François Lefrère, Alan Eli Lichtin, Michael D Tarantino, Howard R Terebelo, Jean-François Viallard, Francis J Cuevas, Ronald S Go, David H Henry, Robert L Redner, Lawrence Rice, Martin R Schipperus, D Matthew Guo, Janet L Nichol

    Lancet
    Efficacy of Romiplostim in Patients with Chronic Immune Thrombocytopenic Purpura: a Double-blind Randomised Controlled Trial

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    Shumway, Nathan M and Wilson, Ramey L and Howard, Robin S and Parker, Joseph M and Eliasson, Arn H
    Respiratory Medicine
    Presence and treatment of air hunger in severely ill patients

    Roger Lyons
    Kantarjian H, Giles F, List A, Sekeres MA, Pierce S, Deuson R, Leveque J.

    Cancer
    The Incidence and Impact of Thrombocytopenia in Myelodysplastic Syndromes

    Download full publication here.

    Roger Lyons, MD
    Hagop Kantarjian, MD, Francis Giles, MD, Alan List, MD, Mikkael A. Sekeres, MD, Sherry Pierce, BSN, Robert Deuson, PhD, Joseph Leveque, MD

    Cancer
    The Incidence and Impact of Thrombocytopenia in Myelodysplastic Syndromes

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    DeZee, Kent J and Shimeall, William T and Douglas, Kevin M and Shumway, Nathan M and O’Malley, Patrick G
    Archives of Internal Medicine
    Treatment of excessive anticoagulation with phytonadione (vitamin K): a meta-analysis

    Roger M. Lyons, MD
    Steven R. Deitcher, MD, Craig M. Kessler, MD, Geno Merli, MD, James R. Rigas, MD, Roger M. Lyons, MD, Jawed Fareed, PhD

    Clinical and Applied Thrombosis/Hemostasis
    Secondary Prevention of Venous Thromboembolic Events in Patients With Active Cancer: Enoxaparin Alone Versus Initial Enoxaparin Followed by Warfarin for a 180-Day Period

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    Roger M. Lyons, M.D.
    James B. Bussel, M.D., David J. Kuter, M.D., D.Phil., James N. George, M.D., Robert McMillan, M.D., Louis M. Aledort, M.D., George T. Conklin, M.D., Alan E. Lichtin, M.D., Jorge Nieva, M.D., Jeffrey S. Wasser, M.D., Israel Wiznitzer, M.D., Reggie Kelly, B.S., Chien-Feng Chen, Ph.D., Janet L. Nichol, M.S.

    New England Journal of Medicine
    AMG 531, a Thrombopoiesis-Stimulating Protein, for Chronic ITP

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    Reese, AM, Farnett, LE, Lyons, RM, Patel, B, Morgan, L, Bussey, HI.
    Pharmacotherapy
    Low dose vitamin K to augment anticoagulation control.
    Shumway, Nathan M and Weiss, Brendan M and Ketchum, Lloyd H and Reid, Thomas J
    Blood
    Hematology Consultation along with the 4 T’s Clinical Scoring System Improves the Evaluation and Management of Heparin Induced Thrombocytopenia.
    Wilson, Ramey L and Eliasson, Arn H and Shumway, Nathan M and Howard, Robin S and Shorr, Andrew F and Parker, Joseph M
    CHEST Journal
    Treating Air Hunger at End-of-Life
    Shumway, Nathan M and Eliasson, Arn H and Wilson, Ramey L and Howard, Robin S and Shorr, Andrew F and Parker, Joseph M
    CHEST Journal
    Prospective Observation of Air Hunger in Severely Ill Patients
    George, JM, Raskob, GE, Vesely, Moore, D, Lyons, RM, Cobos, E, Towell, BL,  Klug, PP, and Guthtie, TH.
    American Journal of Hematology
    Initial management of immune thrombocytopenic purpura in adults: a randomized controlled trial comparing intermittent anti-D with routine care. 
    Evidence-based review of tinzaparin sodium and guidelines for administration
    Clinical Advances in Hematology & Oncology
    Lyons, RM, Andersen, JC, Frame, DG, et al.
    Lawson RS
    Department of Radiation Oncology Grand Rounds. Emory University School of Medicine
    RadioOncologic principles in the Treatment of Skin Cancers
    Lawson RS
    Grady Hospital School of Radiotherapy, resident lecture series
    Genitourinary Malignancies
    Lawson RS
    Resident Research Day, Emory University School of Medicine
    Benefits and Pitfalls of IMRT in Whole Lung Irradiation in Children
    Shumway NM, Kelly WF, Moquin ME, Eliasson AH.
    American Thoracic Society ATS
    Treatment of air hunger at end of life
    Lawson RS
    Resident Research Day, Emory University School of Medicine
    Stereotactic Radiosurgery vs. Intensity Modulated Radiosurgery: Cheers and Challenges
    Lawson RS
    Department of Radiation Oncology Grand Rounds, Emory University School of Medicine
    Review of Cumnt Treatment for Anal Cancer
    Susanto I, Wright SE, Lawson RS, Williams CE, Deneke SM
    American Journal of Physiology
    Metallothionein, glutathione, and cysteine transport in pulmonary artery endothelial cells and NIH/3T3 cells
    Whitling, AM, Bussey, HI, Lyons, RM.
    Archives of Internal Medicine
    Comparing different routes and doses of phytonadione for reversing excessive anticoagulation.
    Amato, MG, Bussey, HI, Farnett, LE, Lyons, RM.
    JAMA
    Acetominophen and risk factors for excess anticoagulation with warfarin.
    Bussey, HI, Lyons, RM.
    Pharmacotherapy
    Controversies in antithrombotic therapy for patients with mechanical heart valves.
    Spiro, TE, Christi M, Lyons, RM, Temaine MD, MacFarlaine DE, Blasier, RB
    Annals of Internal Medicine
    Efficacy & safety of enoxaparin for prevention of deep venous thrombosis after hip replacement surgery. Enoxaparin Clinical Trial Group.
    Adkins, DR, Salzman, D, Boldt, D, Kuhn, J, Irvin, R, Roodman, GD, Lyons, RM, Smith, L, Freytes, CO, Lemaistre, CF.
    Journal of Clinical Oncology
    Phase I trial of dacarbazine with cyclophosphamide, carmustine, etoposide, and autologous stem-cell transplantation in patients with lymphoma and multiple myeloma.
    Lyons, RM.
    Bexar County Medical News
    Thrombolytic therapy for coronary artery thrombosis.
    Lieu, Y, Lyons, RM, McDonagh, J. 
    Thrombosis and Hemostasis
    An abnormal plasminogen with a more cathodic migration:  decreased activation and associated thrombosis.
    Shaw, JO, Brodersen, I, Lyons, RM
    Agents and Actions
    Extra and intracellular Ca2+ requirements for lysosomal enzyme secretion in human neutrophils.
    Lyons, RM, Shaw, JO.
    Journal of Clinical Investigation
    Interaction of Ca2+ and protein phosphorylation in the rabbit platelet release reaction.
    Lyons, RM.
    Thrombosis Research
    Compartmentalization of adenosine 3’: 5” –monophosphate – binding proteins in human platelets.
    Lyons, RM, Atherton, RM.
    Biochemistry
    Characterization of a platelet protein phosphorylated during the thrombin induced release reaction.
    Rutstein, JE, Holahan, JF, Lyons, RM, and Pope, RM.
    Journal of Laboratory and Clinical Medicine
    Rheumatoid factor interference with the latex agglutination test for fibrin degradation products.
    Fisher, BL, Lyons, RM, and Sears, DA.
    American Journal of Hematology
    Development of chronic myelocytic leukemia during the course of acute lymphocytic leukemia in an adult.
    Lyons, RM, Chaplin, H., Tillack, TW, and Majerus, PW.
    Blood
    Gamma heavy chain disease: rapid, sustained response to cyclophosphamide and prednisone.
    Lyons, RM, Stanford, N, Majerus, PW.
    Journal of Clinical Investigation
    Thrombin-induced protein phosphorylation in human platelets.
    Lyons, RM and Goldenberg, GJ.
    Cancer Research
    Active transport of nitrogen mustard and choline by normal and leukemic human lymphoid cells.
    Goldenberg, GJ, Lyons, RM, Lepp, JA, and Vanstone, CL
    Cancer Research
    Sensitivity to nitrogen mustard as a function of transports activity and proliferative rate in L5178Y lymphoblasts.