We are closed on November 23rd and November 24th in observance of Thanksgiving. View More Important Notifications x
texas oncology more breakthroughs. more victories
  • Request an Appointment
  • Find a cancer center
  • Find a provider
  • Clinical Trials

San Antonio Publications

A list of recent publications related to cancer research conducted by our San Antonio physicians.

Date
Physicians
Publication
Title
    Berenson J, Manges R, Badarinath S, Cartmell A, McIntyre K, Lyons R, Harb W, Mohamed H, Nourbakhsh A, Rifkin R.
    American Journal of Hematology 
    A phase 2 safety study of accelerated elotuzumab infusion, over less than 1 hour, in combination with lenalidomide and dexamethasone, in patients with multiple myeloma
    Bersabe AR, Aden JK, Shumway NM, Osswald MB
    Journal of Clinical and Diagnostic Research
    Peripheral Smear Review and Bone Marrow Biopsy Correlation

    Download full publication here.

    Cines DB, Wasser J, Rodeghiero F, Chong BH, Steurer M, Provan D, Lyons R, Garcia-Chavez J, Carpenter N, Wang X, Eisen M.
    Haematologica
    Safety and efficacy of romiplostim in splenectomized and nonsplenectomized patients with primary immune thrombocytopenia.
    Roger M. Lyons, M.D., FACP
    Leukemia Research
    Relation Between Chelation and Clinical Outcomes in Lower-Risk Patients with Myelodysplastic Syndromes
    Mittendorf E.A., Ardavanis A., Symanowski J., Murray J.L., Shumway N.M., Litton J.K., Hale D.F., Perez S.A., Anastasopoulou E.A., Pistamaltzian N.F., Ponniah S., Baxevanis C.N., von Hofe E., Papamichail M., Peoples G.E.
    Annals of Oncology
    Primary analysis of a prospective, randomized, single-blinded phase II trial evaluating the HER2 peptide AE37 vaccine in breast cancer patients to prevent recurrence.
    Jackson, D and Perez, S and Hale, D and Greene, J and Schneble, E and Martin, J and Flores, M and Berry, J and Trappey, A and Vreeland, TJ, Hardin MO, Clifton GT, Herbert GS, Shumway, N, Papamichail M, Mittendorf EA, Peoples GE
    Annals of Surgical Oncology
    Correlation Between Preexisting Immunity and Clinical Response in a Phase II Trial Using HER2-Based Peptide Vaccines to Prevent Breast Cancer Recurrence
    Vreeland TJ, Jackson DO, Hale DF, Greene JM, Schneble EJ, Martin J, Flores M, Berry JS, Trappey AF, Hardin MO, Clifton GT, Herbert GS, Perez S, Shumway N, Papamichail M, Peoples GE, Mittendorf EA.
    Annals of Surgical Oncology
    Efficacy of Booster Inoculations in a Phase II Trial of GP2, a HER2-Derived Peptide Vaccine, for the Prevention of Breast Cancer Recurrence
    Hardin MO, Jackson DO, Hale DF, Greene JM, Schneble EJ, Martin J, Flores M, Berry JS, Trappey AF, Vreeland TJ, Clifton GT, Herbert GS, von Hofe E, Perez S, Shumway N, Papamichail M, Peoples GE, Mittendorf EA. 
    Annals of Surgical Oncology
    Impact of Boosting in the Phase II Trial of the AE37+ GM-CSF Vaccine in High-risk Breast Cancer Patients to Prevent Recurrence
    Wilks, Sharon T. & Schnadig, Ian
    Future Oncology
    APF530 (Granisetron Inj Extended-Release) in a Three-Drug Regimen for Delayed CINV in Highly Emetogenic Chemotherapy
    Chiu L., Chow R., Popovic M., Navari R.M., Shumway N.M., Chiu N., Lam H., Milakovic M., Pasetka M., Vuong S., Chow E., DeAngelis C.
    Support Care Cancer
    Efficacy of olanzapine for the prophylaxis and rescue of chemotherapy-induced nausea and vomiting (CINV): a systematic review and meta-analysis.
    Wilks, Sharon T., Yardley, etal.
    American Society of Clinical Oncology
    Weekly nab-Paclitaxel plus Gemcitabine (Gem) or Carboplatin (Carbo) versus Gem/Carbo as First Line Treatment for Metastatic Triple Negative (mTNBC) in a Phase II/III Trial (TnAcity).
    Wilks, Sharon T., Slamon, et al.
    American Society of Clinical Oncology
    Predictive Biomarkers of Everolimus efficacy in HER2+ Advanced Breast Cancer: Combined Exploratory Analysis from BOLERO-1 and BOLERO-3.
    Bersabe, Adrian REYES and Osswald, Michael B and Shumway, Nathan M
    ASCO Annual Meeting Proceedings
    Correlation of peripheral blood smear review and bone marrow biopsies for benign hematology Outpatient referrals.
    Greene JM, Schneble EJ, Martin J, Flores M, Berry, Trappey AF, Vreeland TJ, Hale DF, Sears AK, Clifton GT, von Hofe E, Ardavannis A, Shumway N, Ponniah S, Papamichail M, Perez S, Symanowski JT, Peoples GE, Mittendorf EA.
    ASCO Annual Meeting Proceedings
    Final pre-specified analysis of the phase II trial of the AE37+ GM-CSF vaccine in high risk breast cancer patients to prevent recurrence.
    Wilks, S. & McIntyre, K
    Clinical Medicine Insights: Oncology
    Case Studies in the Management of Metastatic Breast Cancer with Eribulin.
    Andre, Fabrice, Sara Hurvitz, Angelica Fasolo, Ling-Ming Tseng, Guy Jerusalem, Sharon Wilks, Ruth O’Regan, Claudine Isaacs, Masakazu Toi, Howard Burris, Wei He, Douglas Robinson, Markus Riester Riester, Tetiana Taran, David Chen and Dennis Salmon
    Journal of Clinical Oncology
    Molecular Alterations and Everolimus  Efficacy in HER2-Overexpressing Metastatic Breast Cancers: Combined Exploratory Analysis from BOLERO-1 and BOLERO-3.
    Shumway, Nathan M and Dacus, Jennifer J and Lathrop, Kate I and Hernandez, Elizabeth P and Miller, Maria and Karnad, Anand B
    Journal of Graduate Medical Education
    Use of milestones and development of entrustable professional activities in 2 hematology/oncology training programs
    Shumway, Nathan M and Terrazzino, Sandra E and Jones, Christopher B
    Journal of Pain Management
    A randomized pilot study comparing olanzapine (Zyprexa) to aprepitant (Emend) for treatment of chemotherapy-induced nausea and vomiting
    Wilks, S. et al
    San Antonio Breast Cancer Symposium
    Phase I study of GR antagonist Mifepristone (M) in combination with Eribulin (E)in advanced solid tumors, with dose expansion in patients (pts)with GR-positive Triple Negative Breast Cancer (TNBC).
    Schnadig, Ian; Wilks, Sharon T.
    San Antonio Breast Cancer Symposium
    Phase 3 Comparison of APF530 versus Ondansetron, Each in a Guideline-Recommended 3-drug Regimen for Prevention of Chemotherapy Induced Nausea and Vomiting due to Anthracycline+ Cyclophosphamide (AC) Based Highly Emetogenic Chemotherapy (HEC) Regime.
    O’Shaughnessy, J. et al., Wilks Sharon T.
    Springer Plus Open Journal Volume 4
    Impact of Prior Anthracycline or Taxane on Eribulin Effectiveness as First-Line Treatment for Metastatic Breast Cancer: Results from Two Phase 2, Multicenter, Single-arm Studies.
    Wilks, Sharon T.
    The Breast
    Potential of Overcoming Resistance to HER2-Targeted Therapies through the PI3K/Akt/mTOR pathway.
    Shumway NM, Lathrop KI, Dacus JJ, Miller M, Hernandez EP, Karnad AB
    Accreditation Council of Graduate Medical Education
    Use Of Milestones And Development Of Entrustable Professional Activities (EPAs) In Hematology/Oncology (HO) Training Programs -- A Proactive And Practical Approach to a New Evaluation System.
    Shumway, Nathan M and Dacus, Jennifer Jill and Lathrop, Kate Ida and Hernandez, Elizabeth P and Miller, Maria and Karnad, Anand B
    ASCO Annual Meeting Proceedings
    Informed consent training for medical oncology fellows: Checklist-based simulation exercise.
    Dacus, Jennifer Jill and Shumway, Nathan M and Lathrop, Kate Ida and Hernandez, Elizabeth P and Miller, Maria and Karnad, Anand B
    ASCO Annual Meeting Proceedings
    Chemotherapy infusion reaction training for medical oncology fellows: A checklist-based simulation exercise.
    Mittendorf EA, Schneble EJ, Perez S, Symanowski JT, Patil R, Vreeland TJ, Berry JS, Trappey AF, Hale DF, Sears AK, Clifton GT, von Hofe E, Ardavannis A, Ponniah S, Shumway N, Papamichail M, Peoples GE. 
    ASCO Annual Meeting Proceedings
    Primary analysis of the prospective, randomized, phase II trial of GP2+ GM-CSF vaccine versus GM-CSF alone administered in the adjuvant setting to high-risk breast cancer patients
    Erika J Schneble, Sonia A. Perez, John S. Berry, Alfred F Trappey, Tim Vreeland, Diane F. Hale, Alan K. Sears, Guy T. Clifton, Eric von Hofe, Alexandros Ardavanis, Nathan M. Shumway, Sathibalan Ponniah, Michael Papamichail, George Earl Peoples, Elizabeth Ann Mittendorf
    ASCO Annual Meeting Proceedings
    Comparison of recurrent and nonrecurrent breast cancer patients undergoing AE37 peptide vaccine therapy.
    Elizabeth Ann Mittendorf, Erika J Schneble, Sonia A. Perez, James T Symanowski, Ritesh Patil, Timothy J. Vreeland, John S. Berry, Alfred F Trappey, Guy T. Clifton, Eric von Hofe, Alexandros Ardavanis, Sathibalan Ponniah, Nathan M. Shumway, Michael Papamichail, George Earl Peoples
    ASCO Annual Meeting Proceedings
    Primary analysis of the prospective, randomized, single-blinded phase II trial of AE37 vaccine versus GM-CSF alone administered in the adjuvant setting to high-risk breast cancer patients.
    Bersabe, Adrian R and Osswald, Michael and Shumway, Nathan M
    Blood
    Peripheral Blood Smear Utilization within a Military Hematology/Oncology Fellowship Program
    Wilks, Sharon et al
    Clinical Breast Cancer
    Phase 2, Multicenter, Single-Arm Study of Eribulin Mesylate + Trastuzumab as First Line Therapy for Locally Recurrent or Metastatic HER2 Positive Breast Cancer.

    Roger M. Lyons

    International Blood Research & Reviews
    Iron Overload, Chelation Therapy and Survival in Lower-risk Myelodysplastic Syndromes: State of Evidence

    Download full publication here.

    Graham LJ, Shupe MP, Schneble EJ, Flynt FL, clemenshaw MN, Kirkpatrick AD, Gallagher C, Nissan A, Henry L, Stojadinovic A, Peoples GE, Shumway NM
    Journal of Cancer
    Current approaches and challenges in monitoring treatment responses in breast cancer
    Schneble EJ, Graham LJ, Shupe MP, Flynt FL, Banks KP, Kirkpatrick AD, Nissan A, Henry L, Stojadinovic A, Shumway NM, Avital I, Peoples GE, Setlik RF. 
    Journal of Cancer
    Current approaches and challenges in early detection of breast cancer recurrence
    Shupe, Matthew P and Graham, Lindsey J and Schneble, Erika J and Flynt, Frederick L and Clemenshaw, Michael N and Kirkpatrick, Aaron D and Stojadinovic, Alexander and Peoples, George E and Shumway, Nathan M
    Journal of Cancer
    Future directions for monitoring treatment responses in breast cancer
    Schneble EJ, Graham LJ, Shupe MP, Flynt FL, Banks KP, Kirkpatrick AD, Nissan A, Henry L, Stojadinovic A, Shumway NM, Avital I, Peoples GE, Setlik RF.
    Journal of Cancer
    Future directions for the early detection of recurrent breast cancer
    Wilks, Sharon T., Andre, Fabrice, etal
    The Lancet Oncology
    Everolimus for Women with Trastuzumab Resistant, HER2 Positive, Advanced Breast Cancer (BOLERO-3): A Randomized, Double Blind, Placebo Controlled Phase III Trial.

    Roger Lyons
    Uwe Platzbecker, Raymond SM Wong, Amit Verma, Camille Abboud, Sergio Araujo, Tzeon-Jye Chiou, John Feigert, Su-Peng Yeh, Katharina Götze, Norbert-Claude Gorin, Peter Greenberg, Suman Kambhampati, Yoo-Jin Kim, Je-Hwan Lee, Marco Ruggeri, Valeria Santini, Gregory Cheng, Jun Ho Jang, Chien-Yuan Chen, Souria Dougherty, Frank Mannino, Yasser Mostafa Kamel, Geoffrey Chan, Michael Arning, Nicole Stone, Aristoteles Giagounidis

    18th Congress of the European Hematology Association
    Placebo-controlled, Randomized, Phase I/II Trial of the Thrombopoeitin Receptor Agonist Eltrombopag in Thrombocytopenic Patients with Advanced Myelodysplastic Syndromes or Acute Myeloid Leukemia

    Download full publication here.

    Roger M. Lyons, MD
    Gary E Raskob, PhD, Harry Buller, MD, PhD, Pantep Angchaisuksiri, MD, Doyeun Oh, MD, PhD, Zoltan Boda, MD, PhD, DSc, Jeffrey I. Weitz, MD, George Zhang, PhD, Hans J Lanz, MD, Michele Mercuri,
    MD, PhD, FAHA

    55th American Society of Hematology Annual Meeting and Exposition
    Edoxaban for Long-Term Treatment of Venous Thromboembolism in Cancer Patients 

    Download full publication here.

    Roger M. Lyons, MD
    Srdan Verstovsek, MD, PhD, Ruben A. Mesa, MD, Jason Gotlib, MD, MS, Richard S. Levy, MD, Vikas Gupta, MD, FRCP, FRCPath, John F. Dipersio, MD, PhD, John V. Catalano, MD, Michael W. Deininger, MD, PhD, Carole B. Miller, MD, Richard T. Silver, Moshe Talpaz, MD, Elliott F. Winton, MD, Jimmie H. Harvey Jr., MD, Murat O. Arcasoy, MD, Elizabeth Hexner, MD, Ronald Paquette, MD, Azra Raza, MD, Kris Vaddi, PhD, William Sun, PhD, Wei Peng, PhD, Victor A. Sandor, MD, CM, Hagop M. Kantarjian, MD

    55th American Society of Hematology Annual Meeting and Exposition
    Long-Term Outcomes of Ruxolitinib Therapy in Patients with Myelofibrosis: 3-Year Update From COMFORT-1

    Download full publication here.

    Roger M. Lyons, MD
    Paul J. Shaughnessy, MD, Ann Kelley, RN, Roberta Tremper, RN, Jonathan Tinker, Carlos Bachier, MD, Joseph Holahan, MD, Charles F. LeMaistre, MD

    55th American Society of Hematology Annual Meeting and Exposition
    The VIP (Very Immunocompromised Patient ) Protocol: Improved Access to Care and Time to Antibiotics

    Download full publication here.

    Roger M. Lyons
    Uwe Platzbecker, MD, PhD, Raymond S.M. Wong, Amit Verma, MD, Camille N. Abboud, MD, Sergio Araujo, Tzeon-Jye Chiou, MD, John Feigert, MD, Su-Peng Yeh, MD, Katharina Götze, M.D., Norbert Claude Gorin, MD, PhD, Peter L. Greenberg, MD, Suman Kambhampati, MD, Yoo Jin Kim, MD, Je-Hwan Lee, Marco Ruggeri, MD, Valeria Santini, MD, Gregory Cheng, Jun Ho Jang, Chien-Yuan Chen, Souria Hasan Dougherty, Frank Mannino, Yasser Mostafa Kamel, Geoffrey W. Chan, MD, Nicole L. Stone, PhD, Aristoteles Giagounidis, MD

    55th American Society of Hematology Annual Meeting and Exposition
    Randomized, Placebo-Controlled, Phase I/II Trial of the Thrombopoietin Receptor (TPO-R) Agonist Eltrombopag in Thrombocytopenic Patients with Advanced Myelodysplastic Syndromes or Acute Myeloid Leukemia—A Subgroup Analysis of Patients Receiving Concomitant Anticancer Therapy

    Download full publication here.

    Roger M. Lyons, MD
    Billie J. Marek, MD, Carole S. Paley, MD, Jason Esposito, MSHS, Katie McNamara, MSHS, CCRA, Lawrence Garbo, MD, Nicholas DiBella, MD, Guillermo Garcia-Manero, MD

    55th American Society of Hematology Annual Meeting and Exposition
    48-Month Update on Survival and AML Transformation in a 600-Patient Registry of Lower-Risk MDS Patients

    Download full publication here.

    Vreeland, TJ and Berry, JS and Trappey, AF and Hale, D and Clifton, GT and Sears, A and Shumway, NM and Holmes, JP and Ponniah, S and Mittendorf, EA and others
    Annals Of Surgical Oncology
    Use of an Attenuated Version of a Strongly Immunogenic, Peptide-based Vaccine to Enhance an Anti-cancer Immune Response against Folate Receptor-alpha (FR alpha)
    Patil, Ritesh and Clifton, Guy T and Litton, Jennifer Keating and Shumway, Nathan M and Vreeland, Timothy J and Berry, John S and Trappey, Alfred F and Ponniah, Sathibalan and Peoples, George Earl and Mittendorf, Elizabeth Ann
    ASCO Annual Meeting Proceedings
    Safety and efficacy of the HER2-derived GP2 peptide vaccine in combination with trastuzumab for breast cancer patients in the adjuvant setting.
    Trappey, Alfred F and Berry, John S and Vreeland, Timothy J and Hale, Diane F and Sears, Alan K and Ponniah, Sathibalan and Perez, Sonia A and Clifton, Guy T and Papamichail, Michael and Shumway, Nathan M and others
    ASCO Annual Meeting Proceedings
    Risk factors for development of delayed urticarial reactions in the phase II trial of HER2 peptide vaccines plus GM-CSF versus GM-CSF alone in high-risk breast cancer patients to prevent recurrence.

    Roger M. Lyons
    Srdan Verstovsek, Ruben A. Mesa, Jason Gotlib, Richard S. Levy, Vikas Gupta, John F. DiPersio, John V. Catalano, Michael Deininger, Carole Miller, Richard T. Silver, Moshe Talpaz,11 Elliott F. Winton, Jimmie H. Harvey Jr, Murat O. Arcasoy, Elizabeth Hexner, Ronald Paquette, Azra Raza, Kris Vaddi, Susan Erickson-Viitanen, William Sun, Victor Sandor, Hagop M. Kantarjian

    British Journal of Haematology
    The Clinical Benefit of Ruxolitinib Across Patient Subgroups: Analysis of a Placebo-controlled, Phase III Study in Patients with Myelofibrosis

    Download full publication here.

    Roger M Lyons
    DJ Kuter, JB Bussel, A Newland, RI Baker, J Wasser, JF Viallard, G Macik, M Rummel, K Nie, S Jun.

    British Journal of Haematology
    Long-Term Treatment with Romiplostim in Patients with Chronic Immune Thrombocytopenia (ITP): Safety and Efficacy
    Trappey, AF and Berry, JS and Vreeland, TJ and Guy, CT and Diane, HF and Alan, SK and Erika, SJ and Ferrise, L and Shumway, NM and Papamichail, M and others
    Cancer Research
    Abstract P4-13-05: HLA-A2 is not a prognostic indicator in breast cancer: Implications for cancer vaccine trials
    Berry, John S and Trappey, Alfred F and Vreeland, Timothy J and Hale, Diane F and Clifton, Guy T and Sears, Alan K and Shumway, Nathan M and Ponniah, Sathibalan and Holmes, Jarrod P and Ioannides, Constantin and others
    Cancer Research
    Use of an attenuated version of a strongly immunogenic, peptide-based vaccine to enhance an anti-cancer immune response against folate receptor-alpha.
    Vreeland, TJ and John, BS and Trappey, AF and Schneble, EJ and Hale, DF and Clifton, GT and Shumway, NM and Perez, SA and Papamichail, M and Ponniah, S and others
    Cancer Research
    Breast cancer patients with HER2 low-expression: An under-recognized group at significant risk for recurrence
    Berry, JS and Trappey, AF and Vreeland, TJ and Schneble, EJ and Clifton, GT and Hale, DF and Sears, AK and Ponniah, S and Shumway, NM and Mittendorf, EA and others
    Cancer Research
    Preliminary results for the phase 1 trial of a dual HER2 peptide cancer vaccine in breast and ovarian cancer patients

    Roger M. Lyons
    Deirdra R. Terrell, PhD, James N. George, MD, James B. Bussel, MD, MD, FACP, Vinod Pullarkat, MD, Robert L. Redner, MD, Dominik Selleslag, MD, Kun Nie, PhD, Paul Woodard, MD

    Community Oncology
    Self-Administration of Romiplostim in Patients with Chronic Immune Thrombocytopenia (ITP)

    Download full publication here.

    Roger M. Lyons
    Andres Siulnik, Vikas Gupta, Mahmudul Khan, John F. DiPersio, Mari McQuitty, John V. Catalano, Deborah S. Hunter, Laurent Knoops, Michael Deininger, Francisco Cervantes, Carole Miller, Alessandro M. Vannucchi, Richard T. Silver, Tiziano Barbui, Moshe Talpaz, Giovanni Barosi, Elliott F. Winton, Estella Mendeson, Jimmie H. Harvey, Jr, Murat O. Arcasoy, Elizabeth Hexner, Richard Levy, Ronald Paquette, Azra Raza, William Sun, Victor Sandor, Hagop M. Kantarjian, Claire Harrison

    Haematologica
    Comparison of Placebo and Best Available Therapy for the Treatment of Myelofibrosis in the Phase 3 COMFORT Studies

    Download full publication here.

    Roger M. Lyons
    Richard S. Levy, Srdan Verstovsek, Ruben A. Mesa, Jason Gotlib, Vikas Gupta, John F. DiPersio, John V. Catalano, Michael W.N. Deininger, Carole B. Miller, Richard T. Silver, Moshe Talpaz, Elliott F. Winton, Jimmie H. Harvey, Murat O. Arcasoy, Elizabeth O. Hexner, Roger M. Lyons, Ronald Paquette, Azra Raza, Kris Vaddi, Susan Erickson-Viitanen, William Sun, Victor Sandor, and Hagop M. Kantarjian

    Haematologica
    Efficacy, Safety and Survival with Ruxolitinib Treatment in Patients with Myelofibrosis: Results of a Median 2-year Follow-up of COMFORT-1

    Download full publication here.

    Schneble, Erika J and Berry, John S and Trappey, Alfred F and Vreeland, Timothy J and Hale, Diane F and Sears, Alan K and Clifton, Guy T and Ponniah, Sathibalan and Shumway, Nathan M and Mittendorf, Elizabeth A and others
    Journal for Immunotherapy of Cancer
    Vaccine-specific T-cell proliferation in response to a dual peptide cancer vaccine in breast and ovarian cancer patients.

    Roger M Lyons
    Billie J. Marek, Carole S. Paley, Jason Esposito, Lawrence E. Garbo, Nicholas J. DiBella, Guillermo Garcia-Manero

    Journal of Clinical Oncology
    A 36-Month Analysis of Treatment Patterns of Outcomes in Patients with Lower-Risk Myelodysplastic Syndromes from a Prospective Observational Study

    Download full publication here.

    Roger M Lyons
    Moshe Talpaz, Ronald Paquette, Lawrence Afrin, Solomon I Hamburg, Josef T Prchal, Katarzyna Jamieson, Howard R Terebelo, Gregory L Ortega, Ramon V Tiu, Elliott F Winton11, Kavita Natrajan, Olatoyosi Odenike, David Claxton, Wei Peng, Peter O’Neill, Susan Erickson-Viitanen, Lance Leopold, Victor Sandor, Richard S Levy, Hagop M Kantarjian, Srdan Verstovsek

    Journal of Hematology & Oncology
    Interim Analysis of Safety and Efficacy of Ruxolitinib in Patients with Myelofibrosis and Low Platelet Count

    Download full publication here.

    Roger M. Lyons
    Moshe Talpaz, Ronald Paquette, Lawrence Afrin, Solomon I Hamburg, Josef T Prchal, Katarzyna Jamieson, Howard R Terebelo, Gregory L Ortega, Ramon V Tiu, Elliott F Winton, Kavita Natrajan, Olatoyosi Odenike, David Claxton, Wei Peng, Peter O’Neill, Susan Erickson-Viitanen, Lance Leopold, Victor Sandor, Richard S Levy, Hagop M Kantarjian, Srdan Verstovsek

    Journal of Hematology & Oncology
    Interim Analysis of Safety and Efficacy of Ruxolitinib in Patients with Myelofibrosis and Low Platelet Counts

    Download full publication here.

    Wilks, Sharon, et al.
    San Antonio Breast Cancer Symposium
    Phase 2, Multicenter, Single-Arm Study of Eribulin Mesylate + Trastuzumab as First Line Therapy for Locally Recurrent or Metastatic HER2 Positive Breast Cancer.

    Joyce O’Shaughnessy, MD
    Linda Vahdat, MD, Lee Schwartzberg, MD, Sharon Wilks, MD, FACP, Jessicca Rege, PhD, Wenquan Wang, PhD, David Cox, PhD

    35th Annual San Antonio Breast Cancer Symposium
    Eribulin Mesylate with Trastuzumab as First-Line Therapy for Locally Recurrent or Metastatic Human Epidermal Growth Factor Receptor Two (HER2)-Positive Breast Cancer: Preliminary Results from a Phase 2, Multicenter, Single-Arm Study

    Download full publication here.

    Roger M. Lyons, MD
    Srdan Verstovsek, MD, PhD, Ruben A. Mesa, Jason Gotlib, Richard S. Levy, MD, Vikas Gupta, MD, FRCP, FRCPath, John F. DiPersio, MD, PhD, John V. Catalano, MD, Michael W.N. Deininger, MD, PhD, Carole B. Miller, MD, Richard T. Silver, MD, Moshe Talpaz, MD, Elliott F. Winton, MD, Jimmie H. Harvey, Jr., MD, Murat O. Arcasoy, MD, Elizabeth O. Hexner, MD, Ronald Paquette, MD, PhD, Azra Raza, MD, Kris Vaddi, PhD, Susan Erickson-Viitanen, PhD, William Sun, PhD, Victor A. Sandor, MD, CM, Hagop M. Kantarjian, MD

    54th Annual Meeting of the American Society of Hematology
    Long-Term Outcome of Ruxolitinib Treatment in Patients with Myelofibrosis: Durable Reductions in Spleen Volume, Improvements in Quality of Life, and Overall Survival Advantage in COMFORT-1

    Download full publication here.

    Roger M Lyons, MD
    Billie J. Marek, MD, Carole Paley, MD, Jason Esposito, MSHS, Lawrence Garbo, MD, Nicholas DiBella, MD, Guillermo Garcia-Manero, MD

    54th Annual Meeting of the American Society of Hematology
    Relationship Between Chelation and Clinical Outcomes in 600 Lower-Risk MDS Patients: Registry Analysis At 36 Months

    Download full publication here.

    Roger M Lyons, MD
    Sharon T. Wilks, MD, David J. Friedman, MD, PhD, Shelby A Young, RN, BSN, Gail Brown, MD

    54th Annual Meeting of the American Society of Hematology
    Oral Ezatiostat HCL (Telintra), a Glutathione Analog Prodrug GSTP-1Inhibitor, for Treatment of Patients with Myeloid Growth Factor-Resistant Idiopathic Chronic Neutropenia

    Download full publication here.

    Roger M. Lyons, MD
    Douglas B. Cines, MD, Terry B. Gernsheimer, MD, Jeffrey Wasser, MD, Bertrand Godeau, MD, Andrew Provan, MD, Ivy Altomare, Xuena Wang, PhD, Paul Woodard, MD

    54th Annual Meeting of the American Society of Hematology
    Integrated Analysis of Long-Term Safety in Patients with Chronic Immune Thrombocytopenia Treated with Romiplostim

    Download full publication here.

    Roger M. Lyons
    Moshe Talpaz, Ronald Paquette, Lawrence Afrin, Solomon Hamburg, Katarzyna Jamieson, Howard Terebelo, Gregory Ortega, Ramon V. Tiu, Elliott F. Winton, Kavita Natrajan, Olatoyosi Odenike, Wei Peng, Victor A. Sandor, Peter O'Neill, Sue Erickson-Viitanen, Lance Leopold, Richard S Levy, Hagop M Kantarjian, Srdan Verstovsek

    54th Annual Meeting of the American Society of Hematology
    Efficacy, Hematologic Effects, and Dose of Ruxolitinib in Myelofibrosis Patients with Low Starting Platelet Counts (50-100 x 10^9/L): A Comparison to Patients with Normal or High Starting Platelet Counts

    Download full publication here.

    Hale DF, Vreeland TJ, Dabney RS, Clifton GT, Sears AK, Pappou E, Anastosopoulou E, Ardavanis A, Ponniah S, Papamichail M, Perez S, Shumway N, Peoples GE, Mittendorf E.
    American Association for Cancer Research AACR
    Abstract LB-218: Immune response assessment in a phase II trial of AE37 HER2 peptide vaccine

    Roger M Lyons

    American Journal of Medicine
    Myelodysplastic Syndromes: Therapy and Outlook

    Download full publication here.

    Shumway, Nathan M and Struble, Erika J
    ASCO Annual Meeting Proceedings
    Prospective survey study regarding the implementation of new communication skills curriculum for medical oncology trainees.
    Diane F Hale, Sonia A. Perez, Timothy J Vreeland, Alfred F Trappey, Raetasha Sheavette Dabney, John S. Berry, Alexandros Ardavanis, Alan K. Sears, Michael Papamichail, Guy T. Clifton, Efi Pappou, Ritesh Patil, Eleftheria Anastasopoulou, Sathibalan Ponniah, Nathan M. Shumway, George Earl Peoples and Elizabeth Ann Mittendorf 
    ASCO Annual Meeting Proceedings
    An assessment of disease features and immune response in breast cancer patients that did not recur after receiving HER2 peptide, AE37 vaccine in a randomized phase II trial.
    Mittendorf, Elizabeth Ann and Perez, Sonia A and Hale, Diane F and Vreeland, Timothy J and Sears, Alan K and Clifton, Guy T and Ardavanis, Alexandros and Shumway, Nathan M and Murray, James L and Ponniah, Sathibalan and others
    ASCO Annual Meeting Proceedings
    Early efficacy analysis of the AE37 vaccine in patients with HER2 low-expressing and triple-negative breast cancer.
    Dabney, Raetasha Sheavette and Hale, Diane F and Vreeland, Timothy J and Clifton, Guy T and Sears, Alan K and Patil, Ritesh and Ponniah, Sathibalan and Shumway, Nathan M and Peoples, George Earl and Mittendorf, Elizabeth Ann
    ASCO Annual Meeting Proceedings
    Safety and long-term maintenance of anti-HER2 immunity following booster inoculations of the E75 breast cancer vaccine.
    Vreeland TJ, Hale DF, Sears AK, Clifton GT, Pappou E, Dabney RS, Ardavanis A, Patil R, Ponniah S, Anastasopoulou E, Perez SA, Papamichail M, Shumway NM, Peoples GE, Mittendorf EA.
    ASCO Annual Meeting Proceedings
    From bench to bedside: The use of the li-Key technology to improve helper peptides for clinical use in cancer vaccines.
    Hale, DF and Vreeland, TJ and Perez, SA and Berry, JS and Ardavanis, A and Trappey, AF and Tzonis, P and Sears, AK and Clifton, GT and Shumway, NM and others
    Cancer Research
    The combination of trastuzumab and HER2-directed peptide vaccines is safe in HER2-expressing breast cancer patients
    Vreeland, Timothy J and Dabney, Raetasha S and Hale, Diane F and Sears, Alan K and Clifton, Guy T and Zacharia, Athina and Jama, Yusuf and Chiplis, Anna and Mursal, Mohamed and Shumway, Nathan M and others
    Cancer Research
    Immune reconstitution after chemotherapy correlates with increased in vitro immune response in breast cancer patients undergoing peptide vaccine therapy
    Diane F. Hale, Timothy J. Vreeland, Raetasha S. Dabney, G Travis Clifton, Alan K. Sears, Efi Pappou, Eleftheria Anastasopoulou, Alexandros Ardavanis, Sathibalan Ponniah, Michael Papamichail, Sonia Perez, Nathan Shumway, George E. Peoples, Elizabeth Mittendorf
    Cancer Research
    Abstract LB-218: Immune response assessment in a phase II trial of AE37 HER2 peptide vaccine
    JM Greene, EJ Schneble, S Perez, JL Murray, JS Berry, AF Trappey, DF Hale, TJ Vreeland, GT Clifton, A Ardavanis, JK Litton, NM Shumway, M Papamichail, GE Peoples, EA Mittendorf 
    Cancer Research
    Abstract P2-11-01: Final pre-specified analysis of the phase II trial of the GP2+ GM-CSF peptide vaccine in high risk breast cancer patients to prevent recurrence

    R Lyons
    S Verstovsek, R Mesa, J Gotlib, R Levy, V Gupta, J DiPersio, J Catalano, M Deininger, C Miller, R Silver, M Talpaz, E Winton, J Harvey, M Arcasoy, E Hexner, R Paquette, A Raza, K Vaddi, S Erickson-Viitanen, W Sun, V Sandor, H Kantarjian

    European Focus on Myeloproliferative Neoplasms and Myelodysplastic Syndromes
    Consistent Benefit of Ruxolitinib Over Placebo Across Myelofibrosis Patient Subgroups: Results From COMFORT-1

    Download full publication here.

    Hale, Diane F and Clifton, G Travis and Sears, Alan K and Vreeland, Timothy J and Shumway, Nathan and Peoples, George E and Mittendorf, Elizabeth A
    Expert Review of Vaccines
    Cancer vaccines: should we be targeting patients with less aggressive disease?

    Roger M. Lyons
    Moshe Talpaz, Solomon I. Hamburg, Katarzyna Jamieson, Howard R. Terebelo, Lawrence Afrin, Elliott F. Winton, Michael A. Scola, Jimmie Huling Harvey, Chris E. Holmes, Gregory L. Ortega, Josef T. Prchal, Richard T. Silver, Maria R. Baer, Susan Kay Erickson-Viitanen, Peter O'Neill, Wei Peng, Lance Leopold, Hagop Kantarjian, Srdan Verstovsek

    Journal of Clinical Oncology
    Preliminary Safety and Efficacy of Ruxolitinib in Patients with Primary and Secondary Myelofibrosis with Platelet Counts of 50-100x10^9L

    Download full publication here.

    Roger M. Lyons
    Srdan Verstovsek, Ruben A. Mesa, Jason R. Gotlib, Vikas Gupta, John F. DiPersio, John V. Catalano, Michael W.N. Deininger, Carole Brennan Miller, Richard T. Silver, Moshe Talpaz, Elliott F. Winton, Jimmie Huling Harvey, Murat O. Arcasoy, Elizabeth O. Hexner,Ronald Paquette, Azra Raza, William Sun, Hagop Kantarjian

    Journal of Clinical Oncology
    Adverse Events and the Return of Myelofibrosis-Related Symptoms After Treatment Interruption or Discontinuation in the Comfort-I Study

    Download full publication here.

    Roger M. Lyons
    Eunice S Wang, Roger M Lyons, Richard A Larson, Sunil Gandhi, Delong Liu, Carmen Matei, Bart Scott, Kuolung Hu, Allen S Yang

    Journal of Hematology & Oncology
    A Randomized, Double-blind, Placebo-controlled Phase 2 Study Evaluating the Efficacy and Safety of Romiplostim Treatment of Patients with Low or Intermediate-1 Risk Myelodysplastic Syndrome Receiving Lenalidomide

    Download full publication here.

    Roger M Lyons
    Azra Raza1, Naomi Galili1, Deborah Mulford, Scott E Smith, Gail L Brown, David P Steensma, Ralph Boccia, Mikkael A Sekeres, Guillermo Garcia-Manero, Ruben A Mesa

    Journal of Hematology & Oncology
    Phase 1 Dose-ranging Study of Ezatiostat Hydrochloride in Combination with Lenalidomide in Patients with Non-deletion (5q) Low to Intermediate-1 Risk Myelodysplastic Syndrome (MDS)

    Download full publication here.

    Berry, JS and Vreeland, TJ and Trappey, AF and Hale, DF and Clifton, GT and Sears, AK and Patil, R and Shumway, NM and Holmes, JP and McCall, S and others
    Journal of Immunotherapy
    Trends in Circulating Tumor Cells (CTCS) in Multiple Adjuvant (ADJ) Trials of HER2-Specific Peptide Vaccines (PV) in Breast Cancer (BRCA) PTS

    Roger M Lyons
    Srdan Verstovsek, M.D., Ph.D., Ruben A. Mesa, M.D., Jason Gotlib, M.D., Richard S. Levy, M.D., Vikas Gupta, M.D., John F. DiPersio, M.D., Ph.D., John V. Catalano, M.D., Michael Deininger, M.D., Ph.D., Carole Miller, M.D., Richard T. Silver, M.D., Moshe Talpaz, M.D., Elliott F. Winton, M.D., Jimmie H. Harvey, Jr., M.D., Murat O. Arcasoy, M.D., Elizabeth Hexner, M.D., Ronald Paquette, M.D., Azra Raza, M.D., Kris Vaddi, Ph.D., Susan Erickson-Viitanen, Ph.D., Iphigenia L. Koumenis, M.S., William Sun, Ph.D., Victor Sandor, M.D., and Hagop M. Kantarjian, M.D.

    New England Journal of Medicine
    A Double-Blind, Placebo-Controlled Trial of Ruxolitinib for Myelofibrosis

    Download full publication here.

    Roger Lyons
    Ruben Mesa, Jason Gotlib, Richard Levy, Vikas Gupta, John DiPersio, John Catalono, Michael Deininger, Carloe Miller, Richard Silver, Moshe Talpaz, Elliott Winton, Jimmie Harvey, Murat Arcasoy, Elizabeth Hexner, Roger Lyons, Ronald Paquette, Azra Raza, Kris, Vaddi, Sue Erikson-Viitanen, Iphegenia Koumenis, William Sun, Victor Sandor, Hagop Kantarjian

    16th Congress of the European Hematology Association
    Results of Comfort-1, A Randomized, Double-Blind Phase III Trial of the JAK1 and JAK2 Inhibitor Ruxolitinib (INCB018424) Versus Placebo for Patients with Myelofibrosis

    Download full publication here.

    Haney B, Shumway NM, Peoples GE
    Advances in the Management of Triple Negative Breast Cancer
    Advances in the Management of Triple Negative Breast Cancer Ch.9: Targeted therapies: other agents in clinical trials
    Sears, AK and Clifton, GT and Patil, R and Shumway, NM and Carmichael, MG and Van Echo, DC and Holmes, JP and Ponniah, S and Mittendorf, EA and Peoples, GE
    ASCO Annual Meeting Proceedings
    Sequential administration of trastuzumab and a CD8 T-cell-eliciting HER2/neu peptide vaccine in patients with breast cancer compared to trastuzumab alone.
    Clifton, GT and Sears, AK and Patil, R and Shumway, NM and Carmichael, MG and Van Echo, DC and Holmes, JP and McCall, S and Merrill, GA and Ponniah, S and others
    ASCO Annual Meeting Proceedings
    Monitoring of circulating tumor cell trends in a prospective, randomized, placebo-controlled HER2/neu peptide vaccine trial.

    Roger M. Lyons
    Srdan Verstovsek, MD, PhD, Ruben A. Mesa, MD, Jason Gotlib, MD, MS, Richard S. Levy, MD, Vikas Gupta, MD, FRCP, FRCPath, John F. DiPersio, MD, PhD, John Catalano, MD, Michael W. Deininger, Carole B. Miller, MD, Richard T. Silver, MD, Moshe Talpaz, MD, Elliott F. Winton, MD, Jimmie H. Harvey, Jr., MD, Murat O. Arcasoy, MD, Elizabeth Hexner, MD, Ronald Paquette, MD, PhD, Azra Raza, MD, Kris Vaddi, PhD, Sue Erickson-Viitanen, PhD, William Sun, PhD, Victor A. Sandor, MD, CM, Hagop M. Kantarjian

    Blood
    Clinical Burden and Progression of Myelofibrosis in a Controlled Study Population of Placebo-Treated Patients (COMFORT-1)

    Download full publication here.

    Roger M. Lyons
    Azra Raza, MD, Naomi Galili, Ph.D., Deborah Mulford, MD, Scott E. Smith, MD, PhD, FACP, Gail Brown, MD, Lisa Meng, PhD, David P. Steensma, MD, Ralph Boccia, MD, Mikkael A. Sekeres, MD, MS, Guillermo Garcia-Manero, Ruben A. Mesa, MD

    Blood
    Phase I Dose-Ranging Study of Oral Ezatiostat Hydrochloride (Telintra, TLK199) in Combination with Lenalidomide (Revlimid) in Patients with Non-Deletion (5q) Low to Intermediate-1 Risk Myelodysplastic Syndrome (MDS)

    Download full publication here.

    Roger M. Lyons
    Pierre Fenaux, MD, PhD, Hagop M. Kantarjian, Petra Muus, MD, PhD, Richard A. Larson, MD, Mikkael A. Sekeres, MD, MS, Pamela S. Becker, MD, PhD, Catherine Jia, PhD, Allen S. Yang, MD, PhD

    Blood
    Update of an Open-Label Extension Study Evaluating the Long-Term Safety & Efficacy of Romiplostim in Thrombocytopenic Patients with Myelodysplastic Syndromes (MDS)

    Download full publication here.

    Roger M. Lyons, MD
    Srdan Verstovsek, MD, PhD, Ruben A. Mesa, MD, Jason Gotlib, MD, MS, Richard S. Levy, MD, Vikas Gupta, MD, FRCP, FRCPath, John F. DiPersio, MD, PhD, John Catalano, MD, Michael W. Deininger, Carole B. Miller, MD, Richard T. Silver, MD, Moshe Talpaz, MD, Elliott F. Winton, MD, Jimmie H. Harvey Jr., MD, Murat O. Arcasoy, MD, Elizabeth Hexner, MD, Ronald Paquette, MD, PhD, Azra Raza, MD, Kris Vaddi, PhD, Sue Erickson-Viitanen, PhD, William Sun, PhD, Victor A. Sandor, MD, CM, Hagop M. Kantarjian

    Blood
    Consistent Benefit of Ruxolitinib Over Placebo in Spleen Volume Reduction and Symptom Improvement Across Subgroups and Overall Survival Advantage: Results From COMFORT-1

    Download full publication here.

    Roger M. Lyons, MD
    Jeffrey Wasser, MD, Ralph Vincent V. Boccia, MD, Romeo Mandanas, Ingrid Pabinger, Marc Michel IV, Jean-François Viallard, MD-PhD, Xuena Wang, PhD, Richard Lizambri, MD

    Blood
    Use of Rituximab in a Study Comparing the Thrombopoietin Mimetic Romiplostim with Standard of Care (SOC) in Patients with Immune Thrombocytopenia (ITP)

    Download full publication here.

    Roger M. Lyons, MD
    Billie J. Marek1, Surabhi Sharma, Carole Paley, Jason Esposito, Lawrence Garbo, MD, NicholasnDiBella1, Guillermo Garcia-Manero

    Blood
    24-Month Analysis of the Impact of Chelation on Clinical Outcomes in 600 Patient Registry of Lower-Risk MDS Patients

    Download full publication here.

    Roger M. Lyons, MD
    David J. Kuter, MD, DPhil, James B. Bussel, MD, Adrian Newland, FRCP, Jeffrey S. Wasser, MD, James N. George, MD, Gail Macik, MD, Kun Nie, Susie Jun

    Blood
    Long-Term Efficacy and Safety of Romiplostim Treatment of Adult Patients with Chronic Immune Thrombocytopenia (ITP): Final Report from an Open-Label Extension Study

    Download full publication here.

    Sears, Alan K and Perez, Sonia A and Clifton, Guy T and Benavides, Linda C and Gates, Jeremy D and Clive, Kevin S and Holmes, Jarrod P and Shumway, Nathan M and Van Echo, David C and Carmichael, Mark G and others
    Expert Opinion on Biological Therapy
    AE37: a novel T-cell-eliciting vaccine for breast cancer

    Roger M Lyons
    Craig Reynolds, Nicholas Di Bella, William Hyman, Donald A. Richards, Gerald J. Robbins, Mark Vellek, Kristi A. Boehm, Feng Zhan & Lina Asmar

    Investigational New Drugs
    A Phase III Trial of Fludarabine, Cyclophosphamide, and Rituximab vs. Pentostatin, Cyclophosphamide, and Rituximab in B-Cell Chronic Lymphocytic Leukemia

    Download full publication here.

    Roger M. Lyons
    Sharon T Wilks, Shelby Young, Gail L Brown

    Journal of Hematology & Oncology
    Oral Ezatiostat HCl (Telintra, TLK199) and Idiopathic Chronic Neutropenia (ICN): A Case Report of Complete Response of a Patient with G-CSF Resistant ICN Following Treatment with Ezatiostat, a Glutathionie S-transferase P1-1 (GSTP1-1) Inhibitor

    Download full publication here.

    Roger M Lyons
    David Claxton, Harry P. Erba, Stefan Faderl, Martha Arellano, Tibor Kovacsovics, Janice Gabrilove, Dirk Huebner, Pritesh J. Gandhi, Hagop Kantarjian

    Leukemia and Lymphoma
    Outpatient Consolidation Treatment with Clofarabine in a Phase 2 Study of Older Adult Patients with Previously Untreated Acute Myelogenous Leukemia (AML)

    Download full publication here.

    R.M. Lyons
    P. Fenaux, H. Kantarjian, R.A. Larson, M.A. Sekeres, P.S. Becker, P. Muus, C. Jia, A.S. Yang

    Leukemia Research
    Update of an Open-Label Extension Study Evaluating the Long-Term Safety & Efficacy of Romiplostim in Thrombocytopenic Patients with Myelodysplastic Syndromes

    Download full publication here.

    R.M. Lyons
    G. Garcia-Manero, B.J. Marek, N. Martinez-Lopez, J. Esposito, C. Paley, N. DiBella

    Leukemia Research
    A 12-Month Follow-Up of an Ongoing Prospective, Non-Interventional, Multicenter Registry in Iron Overloaded Patients with Lower-Risk Myelodysplastic Syndromes

    Download full publication here.

    Roger M. Lyons
    Nicholas Di Bella, Raymond Taetle, Kathryn Kolibaba, Thomas Boyd, Robert Raju, David Barrera, Ernest W. Cochran Jr, Philip Y. Dien, Peter J. Schlegel, Svetislava J. Vukelja, Julie Boston, Kristi A. Boehm, Yunfei Wang, Lina Asmar

    Blood
    Results of a Phase II Study of Bortezomib in Patients with Relapsed or Refractory Indolent Lymphoma

    Download full publication here.

    Roger M. Lyons, MD
    Pierre Fenaux, MD, PhD, Hagop Kantarjian, MD, Richard A Larson, MD, Mikkael A Sekeres, MD, MS, Pamela Becker, MD, PhD, Petra Muus, MD, PhD, Catherine Jia, PhD,8 Allen S Yang, MD, PhD

     

    Blood
    Update from an Open-Label Extension Study Evaluating the Long-Term Safety and Efficacy of Romiplostim in Thrombocytopenic Patients with Myelodysplastic Syndromes

    Download full publication here.

    Roger M. Lyons
    Hagop Kantarjian, Pierre Fenaux, Mikkael A. Sekeres, Pamela S. Becker, Adam Boruchov, David Bowen, Eva Hellstrom-Lindberg, Richard A. Larson, Petra Muus, Jamile Shammo, Robert Siegel, Kuolung Hu, Janet Franklin, Dietmar P. Berger

    Journal of Clinical Oncology
    Safety and Efficacy of Romiplostim in Patient with Lower-risk Myelodysplastic Syndrome (MDS) and Thrombocytopenia

    Download full publication here.

    Roger M. Lyons
    Hagop M. Kantarjian, Harry P. Erba, David Claxton, Martha Arellano, Tibor Kovascovics, Janice Gabrilove, Michael Craig, Dan Douer, Michael Maris, Stephen Petersdorf, Paul J. Shami, Andrew M. Yeager, Stephen Eckert, Rekha Abichandani, and Stefan Faderl

    Journal of Clinical Oncology
    Phase II Study of Clofarabine Monotherapy in Previously Untreated Older Adults with Acute Myeloid Leukemia and Unfavorable Prognostic Factors

    Download full publication here.

    Shumway, NM and Terrazzino, SE and Jones, CB
    ASCO Annual Meeting Proceedings
    A randomized pilot study comparing aprepitant to olanzapine for treatment of chemotherapy-induced nausea and vomiting
    Shumway, Nathan M and Ibrahim, Nuhad and Ponniah, Sathibalan and Peoples, George E and Murray, James L
    BioDrugs
    Therapeutic Breast Cancer Vaccines

    Roger M. Lyons
    James B. Bussel, David J. Kuter, Vinod Pullarkat, Matthew Guo, Janet L. Nichol

    Blood
    Safety and Efficacy of Long-Term Treatment with Romiplostim in Thrombocytopenic Patients with ITP

    Download full publication here.

    Roger M. Lyons, MD
    Guillermo Garcia-Manero, Billie J. Marek, Noelia Martinez-Lopez, Carole Paley, Peter L. Greenberg

    Blood
    Clinical Parameters in 391 Iron-Overloaded Patients with Lower-Risk MDS Enrolled in a Prospective, Non-Interventional Multicenter Registry

    Download full publication here.

    Roger M. Lyons
    Stefan Faderl, MD, Harry P Erba, David F. Claxton, M.D., M. Arellano, Tibor J. Kovacsovics, MD, Janice Gabrilove, MD, Elizabeth Anderson, Elly Barry, MD, Hagop M. Kantarjian, MD

    Blood
    Outpatient Treatment with Clofarabine in Phase II Study of Older Adult Patients with Previously Untreated Acute Myelogenous Leukemia

    Download full publication here.

    Roger M. Lyons
    Stefan Fader, MD, Harry P Erba, David F. Claxton, M.D, M. Arellano,  Tibor J. Kovacsovics, MD, Janice Gabrilove, MD, Elizabeth Anderson, Elly Barry, MD, Hagop M. Kantarjian, MD

    Blood
    Clorfarabine Produces Durable Remissions in Older Patients with AML with Unfavorable Prognostic Factors and Multiple Comorbidities

    Download full publication here.

    Roger M. Lyons
    Harry P Erba, Stefan Fader, MD, David F. Claxton, MD, M. Arellano, Tibor J. Kovacsovics, MD, Janice Gabrilove, MD, Stephen Eckert, Ph.D, Dirk Huebner, MD, Hagop M. Kantarjian, MD

    Blood
    Single-Agent Clofarabine Produces Durable Remissions in Patients with Acute Myelogenous Leukemia (AML) Who > or = 70, Have Intermediate or Unfavorable Cytogenetics, Antecedent Hematological Disorders (AHD), or 2 or More Unfavorable Prognostic Factors

    Download full publication here.

    Roger M Lyons
    Richard A. Larson, MD, Michael A. Kosmo, MD, Sunil Gandhi, Delong Liu, MD, PhD, Marc Chernoff, Luke Dreisbach, MD, Carmen Matei, Kuolong Hu, Ph, Janet L. Franklin, MD, MPH, Dietmar Berger, MD, PhD

    Blood
    Randomized Phase II Study Evaluating the Efficacy and Safety of Romiplostim Treatment of Patients with Low or Intermediate Risk Myelodysplastic Syndrome (MDS) Receiving Lenalidomide

    Download full publication here.

    Roger M Lyons
    Janice Gabrilove, MD, Stefan Fader, MD, Harry P Erba, David F. Claxton, M.D., M. Arellano, Tibor J. Kovacsovics, MD, Stephen Eckert, Ph.D, Dirk Huebner, MD, Hagop M. Kantarjian, MD

    Blood
    Complete Response to Clofarabine Is Durable and Correlates with Survival in Previously Untreated Older Adults with Acute Myeloid Leukemia (AML) and Unfavorable Prognostic Factors

    Download full publication here.

    Roger M Lyons
    Pierre Fenaux, Hagop Kantarjian, MD, Richard A. Larson, MD, Mikkael A. Sekeres, MD, MS, Pamela S. Becker, MD, PhD, Petra Muus, MD, PhD, Kuolong Hu, PhD, Dietmar Berger, MD, PhD, Janet L. Franklin, MD, MPH

    Blood
    An Open-Label Extension Study Evaluating the Long-Term Safety and Efficacy of Romiplostim in Thrombocytopenic Patients with Myelodysplastic Syndromes (MDS)

    Download full publication here.

    Roger M Lyons
    Ralph V. Boccia, MD, Gail Macik, MD, Romeo A. Mandanas, MD, FACP, Xuena Wang, Richard Lizambri, MD,d Dietmar Berger, MD, PhD

    Blood
    Home Administration of Romiplostim by Patients with Chronic Immune Thrombocytopenia (ITP)

    Download full publication here.

    Roger M. Lyons
    JN George, SD Mathias, RS Go RS, M Guo, DH Henry, RL Redner, L Rice, MR Schipperus

    British Journal of Haematology
    Improved Quality of Life for Romiplostim-Treated Patients with Chronic Immune Thormbocytopenic Purpura: Results from Two Randomized, Placebo-Controlled Trials

    Roger M. Lyons, M.D., F.A.C.P.
    Jamile M. Shammo, M.D., F.A.S.C.P., Lewis R. Silverman, M.D., Bart L. Scott, M.D.

    Clinical Advances in Hematology & Oncology
    Treatment Selection for Myelodysplastic Syndrome Patients in a Community Setting 

    Download full publication here.

    Roger M. Lyons
    Thomas M. Cosgriff, Sanjiv S. Modi, Robert H. Gersh, John D. Hainsworth, Allen L. Cohn, Heidi J. McIntyre, Indra J. Fernando, Jay T. Backstrom, C.L. Beach

    Journal of Clinical Oncology
    Hematologic Response to Three Alternative Dosing Schedules of Azacitidine in Patients with Myelodysplastic Syndromes

    Download full publication here.

    R. M. Lyons
    H. P. Erba, H. M. Kantarjian, D. F. Claxton, M. Arellano, T. J. Kovacsovics, J., Gabrilove, S. Eckert, S. Faderl

    Journal of Clinical Oncology
    Updated Remission Duration and Survival Results of Single-agent Clofarabine in Previously Untreated Older Adult Patients with Acute Myelogenous Leukemia Unlikely to Benefit From Standard Induction Chemotherapy Due to Unfavorable Baseline Risk Factor(s)

    Download full publication here.

    Roger M. Lyons, MD
    Nicholas Di Bella, MD, Raymond Taetle, MD, Kathryn S. Kolibaba, MD, Thomas E Boyd, MD, Robert N Raju, MD, David N Barrera, DO, Ernest Cochran, MD, Philip Dien, MD, David Hakimian, MD, Peter J Schlegel, MD, Svetislava J Vukelja, MD, Julie Boston, RN, Kristi A Boehm, MS, Yunfei Wang, MS, Lina Asmar, PhD

    Blood
    Results of a Phase II Study of Bortezomib in Patients with Relapsed or refractory Indolent Lymphoma

    Download full publication here.

    Roger M. Lyons, MD
    Craig Reynolds, MD, Nicholas Di Bella, MD, William J Hyman, MD, Gary L. Lee, MD, Donald A Richards, MD, PhD, Gerald J. Robbins, MD, Mark Vellek, MD, Kristi A Boehm, MS, Feng Zhan, PhD, Lina Asmar, PhD

    Blood
    Phase III Trial of Fludarabine, Cyclophosphamide, and Rituximab Vs. Pentostatin, Cyclophosphamide, and Rituximab in B-Cell Chronic Lymphocytic Leukemia

    Download full publication here.

    Roger M. Lyons, MD
    Harry Paul Erba, MD, PhD, Hagop Kantarjian, David F. Claxton, MD, M. Arellano4, Tibor J. Kovacsovics, MD, Janice Gabrilove, MD, Stephen Eckert, Ph.D, Rekha Abichandani, MD, Stefan Faderl, MD

    Blood
    Phase II Study of Single Agent Clofarabine in Previously Untreated Older Adult Patients with Acute Myelogenous Leukemia (AML) Unlikely to Benefit from Standard Induction Chemotherapy

    Download full publication here.

    Roger M. Lyons, MD
    James George, MD, James B Bussel, MD, Vinod Pullarkat, MD, Robert Redner, MD, Deirdra Terrell, PhD, Kun Nie, PhD, Dietmar Berger, MD, PhD

    Blood
    Self-Injection of Romiplostim by Patients with Chronic Immune Thrombocytopenic Purpura (ITP)

    Download full publication here.

    Roger M. Lyons, MD
    James B. Bussel, David J. Kuter, Vinod Pullarkat, Matthew Guo, Janet L. Nichol

    Blood
    Safety and Efficacy of Long-Term Treatment with Romiplostim in Thrombocytopenic Patients with ITP

    Download full publication here.

    Roger M. Lyons
    Janice Gabrilove, Ronald Paquette, Chaudhry Mushtaq, Mikkael A. Sekeres, Dianne Tomita, Lyndah Dreiling

    British Journal of Haematology
    Phase 2, Single-arm, Trial to Evaluate the Effectiveness of Darbopoetin alfa for Correcting Anaemia in Patients with Myelodysplastic Syndromes

    Download full publication here.

    Roger M. Lyons, MD, FACP
    Richard Stone, MD, Mikkael Sekeres, MD, MS, Guillermo Garcia-Manero, MD

    Clinical Advances in Hematology & Oncology
    Recent Advances in Low- and Intermediate-1--Risk Myelodysplastic Syndrome: Developing a Consensus for Optimal Therapy

    Download full publication here.

    R Lyons
    T. Cosgriff, S. Modi, H. McIntyre, I. Fernando, J. Backstrom, C.L. Beach

    Haematologica
    Rapid Onset of Effectiveness with Three Alternative Azacitidine (AZA) Dosing Regimens in Patients with Myelodysplastic Syndromes (MDS)

    Download full publication here.

    R. Lyons
    H. P. Erba, H. M. Kantarjian, D. Claxton, M. Arellano, T. Kovacsovics, J. Gabrilove, S. Eckert, R. Abichandani, S. Faderl

    Journal of Clinical Oncology
    Phase II Study of Single Agent Clofarabine in Previously Untreated Older Adult Patients with Acute Myelogenous leukemia (AML) Unlikely to Benefit from Standard Induction Chemotherapy

    Download full publication here.

    Weiss, Brendan M and Shumway, Nathan M and Howard, Robin S and Ketchum, Lloyd K and Reid, Thomas J
    Journal of Thrombosis and Thrombolysis
    Optical density values correlate with the clinical probability of heparin induced thrombocytopenia

    Roger M. Lyons
    David J Kuter, James B Bussel, Vinod Pullarkat, Terry B Gernsheimer, Francis M Senecal, Louis M Aledort, James N George, Craig M Kessler, Miguel A Sanz, Howard A Liebman, Frank T Slovick, J Th M de Wolf, Emmanuelle Bourgeois, Troy H Guthrie Jr, Adrian Newland, Jeff rey S Wasser, Solomon I Hamburg, Carlos Grande, François Lefrère, Alan Eli Lichtin, Michael D Tarantino, Howard R Terebelo, Jean-François Viallard, Francis J Cuevas, Ronald S Go, David H Henry, Robert L Redner, Lawrence Rice, Martin R Schipperus, D Matthew Guo, Janet L Nichol

    Lancet
    Efficacy of Romiplostim in Patients with Chronic Immune Thrombocytopenic Purpura: a Double-blind Randomised Controlled Trial

    Download full publication here.

    Shumway, Nathan M and Wilson, Ramey L and Howard, Robin S and Parker, Joseph M and Eliasson, Arn H
    Respiratory Medicine
    Presence and treatment of air hunger in severely ill patients

    R. Lyons
    T. Cosgriff, S. Modi, H. McIntyre, I. Fernando, J. Backstrom, C. L. Beach

    Blood
    Results of the Initial Treatment Phase of a Study of Three Alternative Dosing Schedules of Azacitidine (Vidaza) in Patients with Myelodysplastic Syndromes (MDS)

    Download full publication here.

    Roger Lyons
    James N. George, Francois Lefrere, Alan E. Lichtin, Michael D. Tarantino, Howard R. Terebelo, Jean-Francois Viallard, Reggie Kelly, Matthew Guo, Janet Nichol

    Blood
    Evaluation of AMG 531 Safety in Splenectomized (S) and Nonsplenectomized (NS) Patients with Chronic Immune Thrombocytopenic Purpura (ITP) in Two Randomized Placebo-Controlled Phase 3 Studies

    Download full publication here.

    Roger Lyons
    James N. George, Francis J. Cuevas, Ronald S. Go, David H. Henry, Robert L. Redner, Lawrence Rice, Martin R. Schipperus, Susan D. Mathias, Sue Gao, Matthew Guo, Janet L. Nichol

    Blood
    Health-Related Quality of Life (HRQoL) in Patients with Chronic Immune Thrombocytopenic Purpura (ITP): Results from Two Placebo-Controlled Phase 3 Studies of AMG 531

    Download full publication here.

    Roger Lyons
    Hagop Kantarjian, Pierre Fenaux, Mikkael A. Sekeres, Pamela Becker, Adam Boruchov, David Bowen, Richard Larson, Petra Muus, Jamile Shammo, Michael Ehrman, Kuolung Hu, Janet Nichol

    Blood
    Phase 1/2 Study of AMG 531 in Thrombocytopenic Patients with Low Risk Myelodysplastic Syndrome (MDS): Update on Extended Treatment

    Download full publication here.

    Roger Lyons
    Kantarjian H, Giles F, List A, Sekeres MA, Pierce S, Deuson R, Leveque J.

    Cancer
    The Incidence and Impact of Thrombocytopenia in Myelodysplastic Syndromes

    Download full publication here.

    R. M. Lyons
    T. Cosgriff, S. Modi, H. McIntyre, C. L. Beach, J. T. Backstrom

    Journal of Clinical Oncology
    Tolerability and Hematologic Improvement Assessed Using Three Alternative Dosing Schedules of Azacitidine in Patients with Myelodysplastic Syndromes

    Download full publication here.

    R.M. Lyons
    T. Cosgriff, S. Modi, H. McIntyre, C. L. Beach, J. T. Backstrom

    Journal of Clinical Oncology
    Baseline Predictors of Response to Treatment with Darbepoeitin-alpha (DA) in Anemic Patients with Low-risk Myelodysplastic Syndrome (MDS)

    Download full publication here.

    R. M. Lyons
    H. M. Kantarjian, F. J. Giles, P. Fenaux, P. S. Becker, A. M. Boruchov, D. T. Bowen, E. Hellström-Lindberg, R. A. Larson, P. Muus

    Journal of Clinical Oncology
    Evaluating Safety and Efficacy of AMG 531 for the Treatment of Thrombocytopenic Patients with Myelodysplastic Syndrome (MDS): Preliminary Results of a Phase 1/2 Study

    Download full publication here.

    Roger Lyons
    Hagop M. Kantarjian, Francis Giles, Alan F. List, Roger Lyons, Sherry Price, Robert Deuson, Joseph Leveque

    Journal of Community and Supportive Oncology
    The Incidence and Impact of Thrombocytopenia in Myelodysplastic Syndrome

    Download full publication here.

    R. M. Lyons
    H.M. Kantarjian, F.J. Giles, P. Fenaux, P.S. Becker, A.M. Boruchov, D. Bowen, E. Hellstrom-Lindberg, R.A. Larson, R.M. Lyons, P. Muus

    Journal of Community and Supportive Oncology
    The Efficacy and Safety of Darbopoetin Alfa For Treating Anemia in Low-Risk Myelodysplastic Syndrome Patients: Results After 53-55 Weeks

    Download full publication here.

    Roger Lyons
    David Kuter, James B. Bussel, James George, Louis Aledort, Alan Lichtin, Roger Lyons, Jorge Nieva, Jeffrey Wasser, Emanuelle Bourgeois, Mies Kappers-Klunne, Francois Lefrere, Martin Schipperus, Reggie Kelly, Jenny Christal, Matthew Guo, and Janet Nichol

    Journal of Community and Supportive Oncology
    Long-term Dosing of AMG 531 in Thrombocytopenic Patients with Immune Thrombocytopenic Purpura: 48-week Update

    Download full publication here.

    R. Lyons
    H.M. Kantarjian1, F. Giles, A.F. List, M. Sekeres4, S. Pierce1, R. Deuson, J. Leveque

    Supportive Care Cancer
    Thrombocytopenia in MDS: Incidence and Impact

    Download full publication here.

    R. M. Lyons
    H.M. Kantarjian, F.J. Giles, P. Fenaux, P.S. Becker, A.M. Boruchov, D. Bowen, E. Hellstrom-Lindberg, R.A. Larson, R.M. Lyons, P. Muus

    Supportive Care Cancer
    Evaluating Safety and Efficacy of AMG 531 for the Treatment of Thrombocytopenic Patients with Myelodysplastic Syndrome (MDS): Preliminary Results of a Phase 1/2 Study

    Download full publication here.

    Roger Lyons, MD
    Hagop Kantarjian, MD, Francis Giles, MD, Alan List, MD, Mikkael A. Sekeres, MD, Sherry Pierce, BSN, Robert Deuson, PhD, Joseph Leveque, MD

    Cancer
    The Incidence and Impact of Thrombocytopenia in Myelodysplastic Syndromes

    Download full publication here.

    DeZee, Kent J and Shimeall, William T and Douglas, Kevin M and Shumway, Nathan M and O’Malley, Patrick G
    Archives of Internal Medicine
    Treatment of excessive anticoagulation with phytonadione (vitamin K): a meta-analysis

    Roger M. Lyons
    Louis M. Aledort, Gary Okano, Joseph Leveque

    Blood
    The Clinical and Direct Medical Cost Burden of Splenectomy Among Managed Care Patients with Chronic Immune Thrombocytopenic Purpura (ITP)

    Download full publication here.

    Roger M. Lyons
    Louis M. Aledort, Gary Okano, Joseph Leveque

    Blood
    Retrospective Matched Cohort Study of Immune Thrombocytopenic Purpura (ITP): Complications Related to Corticosteroid (CS) Use

    Download full publication here.

    Roger M. Lyons
    David Kuter, James Bussel, James George, Louis Aledort, Alan Lichtin, Jorge Nieva, Jeffrey Wasser, Emanuelle Bourgeois, Mies Kappers-Klunne, Francois Lefrere, Martin Schipperus, Reggie Kelly, Jenny Christal, Matthew Guo, Janet Nichol

    Blood
    Long-term Dosing of AMG 531 in Thrombocytopenic Patients with Immune Thrombocytopenia Purpura: 48-week Update

    Download full publication here.

    Roger M. Lyons
    Hagop M. Kantarjian, Francis Giles, Alan F. List, Sherry Price, Robert Deuson, Joseph Leveque

    Blood
    The Incidence and Impact of Thrombocytopenia in Myelodysplastic Syndromes (MDS)

    Download full publication here.

    Roger M. Lyons
    Thomas Cosgriff, Sanjiv Modi, Heidi McIntyre, C.L. Beach, Jay T. Backstrom

    Blood
    Hematologic Improvement, Transfusion Independence, and Safety Assessed Using Three Alternative Dosing Schedules of Azacitidine in Patients with Myelodysplastic Syndromes

    Download full publication here.

    Roger M. Lyons
    Janice Gabrilove, Ronald Paquette, Chaudhry Mushtaq, Mikkael A. Sekeres, Hung Lam, Lyndah Dreiling

    Blood
    The Efficacy and Safety of Darbopoetin Alfa For Treating Anemia in Low-Risk Myelodysplastic Syndrome Patients: Results After 53-55 Weeks

    Download full publication here.

    Roger M. Lyons, MD
    Steven R. Deitcher, MD, Craig M. Kessler, MD, Geno Merli, MD, James R. Rigas, MD, Roger M. Lyons, MD, Jawed Fareed, PhD

    Clinical and Applied Thrombosis/Hemostasis
    Secondary Prevention of Venous Thromboembolic Events in Patients With Active Cancer: Enoxaparin Alone Versus Initial Enoxaparin Followed by Warfarin for a 180-Day Period

    Download full publication here.

    Roger M. Lyons
    Hagop M. Kantarjian, Francis Giles, Alan F. List, Sherry Price, Robert Deuson, Joseph Leveque

    Journal of Clinical Oncology
    Darbopoetin Alfa for Treating Anemia in Low-Risk Myelodysplastic Syndrome Patients: Interim Results After 27/28 Weeks

    Download full publication here.

    Roger M. Lyons
    J. Gabrilove, R. Paquette, C. Mushtaq, M. Sekeres, H. Lam, L. Dreiling

    Journal of Clinical Oncology
    Darbepoetin Alfa for Treating Anemia in Patients with Low-Risk Myelodysplastic Syndromes: Exploratory Analysis of Baseline Predictors of Response

    Download full publication here.

    Roger M. Lyons
    S. Anthony, T. Cosgriff, S. Modi

    Journal of Clinical Oncology
    Transfusion Independence Assessed During Three Alternative Dosing Schedules of Azacitidine in Patients with Myelodysplastic Syndromes

    Download full publication here.

    Roger M. Lyons, M.D.
    James B. Bussel, M.D., David J. Kuter, M.D., D.Phil., James N. George, M.D., Robert McMillan, M.D., Louis M. Aledort, M.D., George T. Conklin, M.D., Alan E. Lichtin, M.D., Jorge Nieva, M.D., Jeffrey S. Wasser, M.D., Israel Wiznitzer, M.D., Reggie Kelly, B.S., Chien-Feng Chen, Ph.D., Janet L. Nichol, M.S.

    New England Journal of Medicine
    AMG 531, a Thrombopoiesis-Stimulating Protein, for Chronic ITP

    Download full publication here.

    Shumway, Nathan M and Weiss, Brendan M and Ketchum, Lloyd H and Reid, Thomas J
    Blood
    Hematology Consultation along with the 4 T’s Clinical Scoring System Improves the Evaluation and Management of Heparin Induced Thrombocytopenia.
    Wilson, Ramey L and Eliasson, Arn H and Shumway, Nathan M and Howard, Robin S and Shorr, Andrew F and Parker, Joseph M
    CHEST Journal
    Treating Air Hunger at End-of-Life
    Shumway, Nathan M and Eliasson, Arn H and Wilson, Ramey L and Howard, Robin S and Shorr, Andrew F and Parker, Joseph M
    CHEST Journal
    Prospective Observation of Air Hunger in Severely Ill Patients
    Shumway NM, Kelly WF, Moquin ME, Eliasson AH.
    American Thoracic Society ATS
    Treatment of air hunger at end of life