Sitravatinib + Nivo Adv/Met Urothelial
A Phase 2 Study of Sitravatinib in Combination with Nivolumab in Patients With Advanced or Metastatic Urothelial Carcinoma (516-003) Read More
Phase: II
STAR INCB054828 Urothelial FGF/FGFR
A Phase 2, Open-label, Single-Agent, Multicenter Study to Evaluate the Efficacy and Safety of INCB054828 in Subjects with Metastatic or Surgically Unresectable Urothelial Carcinoma Haboring FGF/FGFR Alterations Read More
Phase: II
STAR INCB054828 Urothelial FGF/FGFR
A Phase 2, Open-label, Single-Agent, Multicenter Study to Evaluate the Efficacy and Safety of INCB054828 in Subjects with Metastatic or Surgically Unresectable Urothelial Carcinoma Haboring FGF/FGFR Alterations Read More
Phase: II
STAR Ph2 enfortumab (ASG-22CE)Urothelial
A single-arm, open-label, multicenter study of enfortumab vedotin (ASG-22CE) for treatment of patients with locally advanced or metastatic urothelial cancer who previously received immune checkpoint inhibitor (CPI) therapy - SGN22E-001 Read More
Phase: II
Ph3 Abemaciclib HR+ HER2- (monarchE)
(I3Y-MC-JPCF) monarchE: A Randomized, Open-Label, Phase 3 Study of Abemaciclib Combined with Standard Adjuvant Endocrine Therapy versus Standard Adjuvant Endocrine Therapy Alone in Patients with High Risk, Node Positive, Early Stage, Hormone Receptor Positive, Human Epidermal Receptor 2 Negative, Breast Cancer Read More
Phase: III
Ph1b BGB-A317 + BGB-290 Adv Solid Tumor
A Phase 1/1b, Open Label, Multiple Dose, Dose Escalationand Expansion Study to Investigate the Safety,Pharmacokinetics and Antitumor Activity of theanti-PD-1 Monoclonal Antibody BGB-A317 inCombination with the PARP Inhibitor BGB-290 inSubjects with Advanced Solid Tumors Read More
Phase: I
Phase 1/2a BMS-986253 + Nivo
A Phase 1/2a Study of BMS-986253 in Combination with Nivolumab in Advanced Cancers (CA027002) Read More
Phase: I/II
Ph1 MSB0011359C Solid Tumors
A Phase I, open-label, multiple-ascending dose trial to investigate the safety, tolerability, pharmacokinetics, biological and clinical activity of MSB0011359C in subjects with metastatic or locally advanced solid tumors and expansion to selected indications - EMD Serono EMR 200647-001 Read More
Phase: I
Adj Therapy Node+orHRNode-3-Inv TNBC
A Randomized Phase III Trial of Adjuvant Therapy Comparing Doxorubicin Plus Cyclophosphamide Followed by Weekly Paclitaxel with or without Carboplatin for Node-Positive or High-Risk Node-Negative Triple-Negative Invasive Breast Cancer (NRG-BR003) Read More
Phase: III
Ph3 Pembro HR+/HER2- BC
A Randomized, Double-Blind, Phase III Study of Pembrolizumab versus Placebo in Combination with Neoadjuvant Chemotherapy and Adjuvant Endocrine Therapy for the Treatment of High-Risk Early-Stage Estrogen Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative (ER+/HER2-) Breast Cancer (MK3475-KN756) Read More
Phase: III
Ph2 SC Pertuz+Trastuz HER2+ BC
A RANDOMIZED, MULTICENTER, OPEN-LABEL CROSS-OVER STUDY TO EVALUATE PATIENT PREFERENCE AND SATISFACTION OF SUBCUTANEOUS ADMINISTRATION OF THE FIXED-DOSE COMBINATION OF PERTUZUMAB AND TRASTUZUMAB IN PATIENTS WITH HER2- POSITIVE EARLY BREAST CANCER (MO40628) Read More
Phase: II
FLEX Registry: Evaluate New Gene Express
MammaPrint, BluePrint, and Full-genome Data Linked with Clinical Data to Evaluate New Gene EXpression Profiles: An Adaptable Registry (FLEX Registry) Read More
Non-Interv study Palbo HR+/HER2 AdvBC
POLARIS: Palbociclib in Hormone Receptor Positive AdvancedBreast Cancer: A Prospective Multicenter Non-Interventional Study (A5481082) Read More
Ph3 SYD985 HER2+ unresect adv/mBC
SYD985.002: A multi-centre, open-label, randomized clinical trial comparing the efficacy and safety of the antibody-drug conjugate SYD985 to physician''s choice in patients with HER2-positive unresectable locally advanced or metastatic breast cancer Read More
Phase: III
Ph1b BGB-A317 + BGB-290 Adv Solid Tumor
A Phase 1/1b, Open Label, Multiple Dose, Dose Escalationand Expansion Study to Investigate the Safety,Pharmacokinetics and Antitumor Activity of theanti-PD-1 Monoclonal Antibody BGB-A317 inCombination with the PARP Inhibitor BGB-290 inSubjects with Advanced Solid Tumors Read More
Phase: I
Ph1 MSB0011359C Solid Tumors
A Phase I, open-label, multiple-ascending dose trial to investigate the safety, tolerability, pharmacokinetics, biological and clinical activity of MSB0011359C in subjects with metastatic or locally advanced solid tumors and expansion to selected indications - EMD Serono EMR 200647-001 Read More
Phase: I
Ph1 TSR-022 Adv Solid Tumors
A Phase 1 Dose Escalation and Cohort Expansion Study of TSR-022, an anti-TIM-3 Monoclonal Antibody, in Patients with Advanced Solid Tumors (4020-01-001) Read More
Phase: I
Phase 1/2a BMS-986253 + Nivo
A Phase 1/2a Study of BMS-986253 in Combination with Nivolumab in Advanced Cancers (CA027002) Read More
Phase: I/II
Ph1 MSB0011359C Solid Tumors
A Phase I, open-label, multiple-ascending dose trial to investigate the safety, tolerability, pharmacokinetics, biological and clinical activity of MSB0011359C in subjects with metastatic or locally advanced solid tumors and expansion to selected indications - EMD Serono EMR 200647-001 Read More
Phase: I
PhI/II PK Multi Tumor SubQ Nivo Mono
Phase I/II pharmacokinetic multi-tumor study of subcutaneous formulation of nivolumab monotherapy (CA2098KX) Read More
Phase: I/II
Ph 1/2 PIM kinase Adv Malignancies
A Phase 1/2 Study of INCB053914 in Subjects With Advanced Malignancies (INCB 53914-101) Read More
Phase: I
Ph3b 1L CLL debulk combo
A phase 3b study in previously untreated Chronic Lymphocytic Leukemia (CLL) subjects, excluding those with the 17p deletion, to evaluate debulking regimens prior to initiating venetoclax combination therapy (M16-788) Read More
Phase: III
informCLL™ Registry
informCLL™: A Disease Registry for Patients with Chronic Lymphocytic Leukemia (PCYC-1134M-CA) Read More
Phase: IV
Ph3 HR MDS, CMML, AML
Pevonedistat-3001: A Phase 3, Randomized, Controlled, Open-label, Clinical Study of Pevonedistat Plus Azacitidine Versus Single-Agent Azacitidine as First-Line Treatment for Patients With Higher-Risk Myelodysplastic Syndromes, Chronic Myelomonocytic Leukemia, or Low-Blast Acute Myelogenous Leukemia Read More
Phase: III
Ph 1/1b Immunotherapy Combo in NSCLC
(AB928CSP0004) A Phase 1/1b Study to Evaluate the Safety and Tolerability of Immunotherapy Combinations in Participants with Lung Cancer Read More
Phase: I
PhIb/2 Lenvatinib (E7080)+Pembro Solids
A Multicenter, Open-Label Phase 1b/2 Trial of Lenvatinib (E7080) Plus Pembrolizumab in Subjects With Selected Solid Tumors (E7080-A001-111) Read More
Phase: I/II
Ph2 MGCDs+Nivo NSCLC
A Parallel Phase 2 Study of Glesatinib, Sitravatinib or Mocetinostat in Combination With Nivolumab in Advanced or Metastatic Non-Small Cell Lung Cancer (MRTX-500) Read More
Phase: II
Ph1 TSR-022 Adv Solid Tumors
A Phase 1 Dose Escalation and Cohort Expansion Study of TSR-022, an anti-TIM-3 Monoclonal Antibody, in Patients with Advanced Solid Tumors (4020-01-001) Read More
Phase: I
Ph1/1b MGCD516 Solid tumors
A Phase 1/1b Study of MGCD516 in Patients With Advanced Solid Tumor Malignancies (516-001) Read More
Phase: I
Ph1b BGB-A317 + BGB-290 Adv Solid Tumor
A Phase 1/1b, Open Label, Multiple Dose, Dose Escalationand Expansion Study to Investigate the Safety,Pharmacokinetics and Antitumor Activity of theanti-PD-1 Monoclonal Antibody BGB-A317 inCombination with the PARP Inhibitor BGB-290 inSubjects with Advanced Solid Tumors Read More
Phase: I
Phase 1/2a BMS-986253 + Nivo
A Phase 1/2a Study of BMS-986253 in Combination with Nivolumab in Advanced Cancers (CA027002) Read More
Phase: I/II
STAR Ph2 Poziotinib EGFR/HER2 NSCLC
A Phase 2 Study of Poziotinib in Patients with Non-Small Cell Lung Cancer (NSCLC), Locally Advanced or Metastatic, with EGFR or HER2 Exon 20 Insertion Mutation (ZENITH20) (SPI-POZ-202) Read More
Phase: II
Ph 3 pembro+ipi, 1L adv/rec NSCLC
A Phase 3, Randomized, Double-Blind Study of Pembrolizumab plus Ipilimumab vs Pembrolizumab plus Placebo in Previously Untreated, Stage IV, Metastatic Non-small Cell Lung Cancer Subjects Whose Tumors are PD-L1 Positive (TPS > or = to 50%) (KEYNOTE-598)- MK-3475-598 Read More
Phase: III
Ph1 MSB0011359C Solid Tumors
A Phase I, open-label, multiple-ascending dose trial to investigate the safety, tolerability, pharmacokinetics, biological and clinical activity of MSB0011359C in subjects with metastatic or locally advanced solid tumors and expansion to selected indications - EMD Serono EMR 200647-001 Read More
Phase: I
Ph3 Adj canakinumab NSCLC
A phase III, multicenter, randomized, double blind, placebo-controlled study evaluating the efficacy and safety of canakinumab versus placebo as adjuvant therapy in adult subjects with stages AJCC/UICC v. 8 II-IIIA and IIIB (T>5cm N2) completely resected (R0) non-small cell lung cancer (NSCLC)(CACZ885T2301) Read More
Phase: III
Cypress 1: Ph 2 AM0010+Pembro NSCLC
An Open-Label Randomized Phase 2 Trial of AM0010 in Combination with Pembrolizumab vs. Pembrolizumab Alone as First-line Therapy in Patients with Stage IV/Metastatic Non-Small Cell Lung Cancer and Tumors With High Expression of PD-L1 (≥ 50%) (AM0010-201; J1L-AM-JZGC) Read More
Phase: II
Atezo Rollover for GNE & Roche
BO39633 (IMbrella A), An open-Label, Multicenter Extension and Long-Term Observational Study in Patients Previously Enrolled in A Genentech- and/or F.Hoffman-La Roche Ltd. sponsored Atezolizumab Study Read More
Phase: II/III
STAR Ph2 Brigatinib ALK+ NSCLC (TAK2002)
Brigatinib in Patients With Anaplastic Lymphoma Kinase-Positive (ALK+), Advanced Non-Small-Cell Lung Cancer (NSCLC) Progressed on Alectinib or Ceritinib (2002) Read More
Phase: II
STAR Ph3 ALK+ mNSCLC (Brigatinib-3001)
Brigatinib-3001- A Phase 3 Randomized Open-label Study of Brigatinib (ALUNBRIG™) Versus Alectinib (ALECENSA®) in Advanced Anaplastic Lymphoma Kinase-Positive Non-Small-Cell Lung Cancer Patients Who Have Progressed on Crizotinib (XALKORI®) Read More
Phase: III
Ph3b/4 Safety Nivo+Ipi 1L, 2L NSCLC
CA209-817: A Phase IIIb/IV Safety and Efficacy Trial of Flat Dose Nivolumab in Combination with Ipilimumab in Participants with Non-Small Cell Lung Cancer Read More
Phase: III/IV
PhI/II PK Multi Tumor SubQ Nivo Mono
Phase I/II pharmacokinetic multi-tumor study of subcutaneous formulation of nivolumab monotherapy (CA2098KX) Read More
Phase: I/II
Ph3 Polatuzumab 1L DLBCL [POLARIX]
(GO39942): A PHASE III, MULTICENTER, RANDOMIZED,DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL COMPARING THE EFFICACY AND SAFETY OF POLATUZUMAB VEDOTIN IN COMBINATION WITH RITUXIMAB AND CHP (R-CHP) VERSUS RITUXIMAB AND CHOP (R-CHOP) IN PREVIOUSLY UNTREATED PATIENTS WITH DIFFUSE LARGE B-CELL LYMPHOMA Read More
Phase: III
Ph3 Rituximab +/- Ibrutinib tx-naive FL
A Multicenter, Randomized, Double-blind, Placebo-controlled Phase 3 Study of the Bruton''s Tyrosine Kinase (BTK) Inhibitor, Ibrutinib, in Combination with Rituximab versus Placebo in Combination with Rituximab in Treatment Naïve Subjects with Follicular Lymphoma - PCYC-1141-CA Read More
Phase: III
Ph2 R/R MCL (CITADEL-205)
A Phase 2, Open-Label, 2-Cohort, Multicenter Study of INCB050465, a PI3Kä Inhibitor, in Relapsed or Refractory Mantle Cell Lymphoma Previously Treated With or Without a BTK Inhibitor (CITADEL-205)- INCB050465-205 Read More
Phase: II
TGR-1202 +/- Ublituximab in NHL
A Phase 2b Randomized Study to Assess the Efficacy and Safety of the Combination of Ublituximab + TGR-1202 with or without Bendamustine and TGR-1202 alone in Patients with Previously Treated Non-Hodgkin''s Lymphoma (UTX-TGR-205) Read More
Phase: II
A Phase 3, Randomized, Double blind, Placebo controlled, Multicenter Study of Bendamustine and Rituximab (BR) Alone Versus in Combination with Acalabrutinib (ACP 196) in Subjects with Previously Untreated Mantle Cell Lymphoma
Phase: III
Ph1b/2 R/R FL, R/R DLBCL
A PHASE Ib/II STUDY EVALUATING THE SAFETY AND EFFICACY OF OBINUTUZUMAB IN COMBINATION WITH POLATUZUMAB VEDOTIN AND LENALIDOMIDE IN PATIENTS WITH RELAPSED OR REFRACTORY FOLLICULAR LYMPHOMA AND RITUXIMAB IN COMBINATION WITH POLATUZUMAB VEDOTIN AND LENALIDOMIDE IN PATIENTS WITH RELAPSED OR REFRACTORY DIFFUSE LARGE B-CELL LYMPHOMA (GO29834) Read More
Phase: I/II
STAR Ph1/2 Tazemetostat r/r DLBCL & FL
An Open-Label, Multicenter, Phase 1/2 Study of Tazemetostat (EZH2 Histone Methyl Transferase [HMT] Inhibitor) as a Single Agent in Subjects With Advanced Solid Tumors or With B Cell Lymphomas and Tazemetostat in Combination With Prednisolone in Subjects With Diffuse Large B Cell Lymphoma - E7438-G000-101 Read More
Phase: I/II
PhIb/2 Lenvatinib (E7080)+Pembro Solids
A Multicenter, Open-Label Phase 1b/2 Trial of Lenvatinib (E7080) Plus Pembrolizumab in Subjects With Selected Solid Tumors (E7080-A001-111) Read More
Phase: I/II
Ph1 TSR-022 Adv Solid Tumors
A Phase 1 Dose Escalation and Cohort Expansion Study of TSR-022, an anti-TIM-3 Monoclonal Antibody, in Patients with Advanced Solid Tumors (4020-01-001) Read More
Phase: I
Ph1/1b MGCD516 Solid tumors
A Phase 1/1b Study of MGCD516 in Patients With Advanced Solid Tumor Malignancies (516-001) Read More
Phase: I
Phase 1/2a BMS-986253 + Nivo
A Phase 1/2a Study of BMS-986253 in Combination with Nivolumab in Advanced Cancers (CA027002) Read More
Phase: I/II
Ph1 MSB0011359C Solid Tumors
A Phase I, open-label, multiple-ascending dose trial to investigate the safety, tolerability, pharmacokinetics, biological and clinical activity of MSB0011359C in subjects with metastatic or locally advanced solid tumors and expansion to selected indications - EMD Serono EMR 200647-001 Read More
Phase: I
PhI/II PK Multi Tumor SubQ Nivo Mono
Phase I/II pharmacokinetic multi-tumor study of subcutaneous formulation of nivolumab monotherapy (CA2098KX) Read More
Phase: I/II
Ph3 TSR-042, Niraparib Ovarian FIRST
3000-03-005/ENGOT-OV44 : A RANDOMIZED, DOUBLE-BLIND, PHASE 3 COMPARISON OF PLATINUM-BASED THERAPY WITH TSR-042 AND NIRAPARIB VERSUS STANDARD OF CARE PLATINUM-BASED THERAPY AS FIRST-LINE TREATMENT OF STAGE III OR IV NONMUCINOUS EPITHELIAL OVARIAN CANCER Read More
Phase: III
Ph1b BGB-A317 + BGB-290 Adv Solid Tumor
A Phase 1/1b, Open Label, Multiple Dose, Dose Escalationand Expansion Study to Investigate the Safety,Pharmacokinetics and Antitumor Activity of theanti-PD-1 Monoclonal Antibody BGB-A317 inCombination with the PARP Inhibitor BGB-290 inSubjects with Advanced Solid Tumors Read More
Phase: I
Ph1 MSB0011359C Solid Tumors
A Phase I, open-label, multiple-ascending dose trial to investigate the safety, tolerability, pharmacokinetics, biological and clinical activity of MSB0011359C in subjects with metastatic or locally advanced solid tumors and expansion to selected indications - EMD Serono EMR 200647-001 Read More
Phase: I
Phase 1/2a BMS-986253 + Nivo
A Phase 1/2a Study of BMS-986253 in Combination with Nivolumab in Advanced Cancers (CA027002) Read More
Phase: I/II
Ph1 MSB0011359C Solid Tumors
A Phase I, open-label, multiple-ascending dose trial to investigate the safety, tolerability, pharmacokinetics, biological and clinical activity of MSB0011359C in subjects with metastatic or locally advanced solid tumors and expansion to selected indications - EMD Serono EMR 200647-001 Read More
Phase: I
FOLFOX +/1 AM0010 Panc
A Randomized Phase 3 Study of AM0010 in Combination with FOLFOX Compared with FOLFOX Alone as Second-line Therapy in Patients with Metastatic Pancreatic Cancer that has Progressed During or Following a First-Line Gemcitabine Containing Regimen (AM0010-301) Read More
Phase: III
PANOVA-3: 1L Gemcit + nab-pac pancreatic
PANOVA-3: Pivotal, randomized, open-label study of Tumor Treating Fields (TTFields, 150kHz) concomitant with gemcitabine and nab-paclitaxel for front-line treatment of locally-advanced pancreatic adenocarcinoma (EF-27) Read More
Phase: III
Ph3 TSR-042, Niraparib Ovarian FIRST
3000-03-005/ENGOT-OV44 : A RANDOMIZED, DOUBLE-BLIND, PHASE 3 COMPARISON OF PLATINUM-BASED THERAPY WITH TSR-042 AND NIRAPARIB VERSUS STANDARD OF CARE PLATINUM-BASED THERAPY AS FIRST-LINE TREATMENT OF STAGE III OR IV NONMUCINOUS EPITHELIAL OVARIAN CANCER Read More
Phase: III
Ph1b BGB-A317 + BGB-290 Adv Solid Tumor
A Phase 1/1b, Open Label, Multiple Dose, Dose Escalationand Expansion Study to Investigate the Safety,Pharmacokinetics and Antitumor Activity of theanti-PD-1 Monoclonal Antibody BGB-A317 inCombination with the PARP Inhibitor BGB-290 inSubjects with Advanced Solid Tumors Read More
Phase: I
Ph1/1b MGCD516 Solid tumors
A Phase 1/1b Study of MGCD516 in Patients With Advanced Solid Tumor Malignancies (516-001) Read More
Phase: I
Ph1b BGB-A317 + BGB-290 Adv Solid Tumor
A Phase 1/1b, Open Label, Multiple Dose, Dose Escalationand Expansion Study to Investigate the Safety,Pharmacokinetics and Antitumor Activity of theanti-PD-1 Monoclonal Antibody BGB-A317 inCombination with the PARP Inhibitor BGB-290 inSubjects with Advanced Solid Tumors Read More
Phase: I
STAR Abirat+pred +/- abemaciclib mCRPC
A Phase 2, Randomized, Double-blind, Placebo-Controlled Study of Abiraterone Acetate Plus Prednisone with or without Abemaciclib in Patients with Metastatic Castration-Resistant Prostate Cancer (I3Y-MC-JPCM) Read More
Phase: II
STAR Ph2 Rucaparib mCRPC (TRITON 2)
TRITON2: A Multicenter, Open-label Phase 2 Study of Rucaparib inPatients with Metastatic Castration-resistant Prostate Cancer Associated with Homologous Recombination Deficiency - CO-338-052 Read More
Phase: II
STAR Rucaparib v PhysC mCRPC (TRITON3)
TRITON3: A Multicenter, Randomized, Open-label Phase 3 Study of Rucaparib versus Physician''s Choice of Therapy for Patients withMetastatic Castration-resistant Prostate Cancer Associated withHomologous Recombination Deficiency (CO-338-063) Read More
Phase: III
Ph1 Solid tumors, RCC
(AB928CSP0005) A Phase 1 Study to Evaluate the Safety and Tolerability of Immunotherapy Combinations in Participants with Advanced Malignancies Read More
Phase: I
PhIb/2 Lenvatinib (E7080)+Pembro Solids
A Multicenter, Open-Label Phase 1b/2 Trial of Lenvatinib (E7080) Plus Pembrolizumab in Subjects With Selected Solid Tumors (E7080-A001-111) Read More
Phase: I/II
Lenvat+ever/pemb vs sunit 1L RCC [CLEAR]
A Multicenter, Open-label, Randomized, Phase 3 Trial to Compare the Efficacy and Safety of Lenvatinib in Combination with Everolimus or Pembrolizumab Versus Sunitinib Alone in First-Line Treatment of Subjects with Advanced Renal Cell Carcinoma(E7080-G000-307)(CLEAR) Read More
Phase: III
Ph1/1b MGCD516 Solid tumors
A Phase 1/1b Study of MGCD516 in Patients With Advanced Solid Tumor Malignancies (516-001) Read More
Phase: I
Phase 1/2a BMS-986253 + Nivo
A Phase 1/2a Study of BMS-986253 in Combination with Nivolumab in Advanced Cancers (CA027002) Read More
Phase: I/II
Ph3 Pembro RCC post nephrectomy
A Phase III, Randomized, Double-Blind, Placebo-Controlled Clinical Trial of Pembrolizumab (MK-3475) as Monotherapy in the Adjuvant Treatment of Renal Cell Carcinoma Post Nephrectomy (KEYNOTE-564) Read More
Phase: III
PhI/II PK Multi Tumor SubQ Nivo Mono
Phase I/II pharmacokinetic multi-tumor study of subcutaneous formulation of nivolumab monotherapy (CA2098KX) Read More
Phase: I/II
Ph1 Solid tumors, RCC
(AB928CSP0005) A Phase 1 Study to Evaluate the Safety and Tolerability of Immunotherapy Combinations in Participants with Advanced Malignancies Read More
Phase: I
Ph1/1b MGCD516 Solid tumors
A Phase 1/1b Study of MGCD516 in Patients With Advanced Solid Tumor Malignancies (516-001) Read More
Phase: I
Ph1b BGB-A317 + BGB-290 Adv Solid Tumor
A Phase 1/1b, Open Label, Multiple Dose, Dose Escalationand Expansion Study to Investigate the Safety,Pharmacokinetics and Antitumor Activity of theanti-PD-1 Monoclonal Antibody BGB-A317 inCombination with the PARP Inhibitor BGB-290 inSubjects with Advanced Solid Tumors Read More
Phase: I
Phase 1/2a BMS-986253 + Nivo
A Phase 1/2a Study of BMS-986253 in Combination with Nivolumab in Advanced Cancers (CA027002) Read More
Phase: I/II
Ph1 FIH TP-1287 Solid tumor
A Phase I, First-in-human, Open-label, Dose-escalation, Safety, Pharmacokinetic, and Pharmacodynamic Study of Oral TP-1287 Administered Twice Daily for 14 Days to Patients with Advanced Solid Tumors (TP-1287-101) Read More
Phase: I
Ph1 MSB0011359C Solid Tumors
A Phase I, open-label, multiple-ascending dose trial to investigate the safety, tolerability, pharmacokinetics, biological and clinical activity of MSB0011359C in subjects with metastatic or locally advanced solid tumors and expansion to selected indications - EMD Serono EMR 200647-001 Read More
Phase: I
An Open-Label, Multicenter, Global Phase 2 Basket Study of Entrectinib for the Treatment of Patients with Locally Advanced or Metastatic Solid Tumors that Harbor NTRK1/2/3, ROS1, or ALK Gene Rearrangements
Phase: II
CheckMate 848: Ph2 Nivo+Ipi Solid tumors
CA209848 - A Randomized, Open-Label, Phase 2 Study of Nivolumab in Combination with Ipilimumab or Nivolumab Monotherapy in Participants with Advanced or Metastatic Solid Tumors of High Tumor Mutational Burden (TMB-H) Read More
Phase: II
PhIb/2 Lenvatinib (E7080)+Pembro Solids
A Multicenter, Open-Label Phase 1b/2 Trial of Lenvatinib (E7080) Plus Pembrolizumab in Subjects With Selected Solid Tumors (E7080-A001-111) Read More
Phase: I/II
Ph1b BGB-A317 + BGB-290 Adv Solid Tumor
A Phase 1/1b, Open Label, Multiple Dose, Dose Escalationand Expansion Study to Investigate the Safety,Pharmacokinetics and Antitumor Activity of theanti-PD-1 Monoclonal Antibody BGB-A317 inCombination with the PARP Inhibitor BGB-290 inSubjects with Advanced Solid Tumors Read More
Phase: I
Phase 1/2a BMS-986253 + Nivo
A Phase 1/2a Study of BMS-986253 in Combination with Nivolumab in Advanced Cancers (CA027002) Read More
Phase: I/II
Sitravatinib + Nivo Adv/Met Urothelial
A Phase 2 Study of Sitravatinib in Combination with Nivolumab in Patients With Advanced or Metastatic Urothelial Carcinoma (516-003) Read More
Phase: II
STAR INCB054828 Urothelial FGF/FGFR
A Phase 2, Open-label, Single-Agent, Multicenter Study to Evaluate the Efficacy and Safety of INCB054828 in Subjects with Metastatic or Surgically Unresectable Urothelial Carcinoma Haboring FGF/FGFR Alterations Read More
Phase: II
STAR INCB054828 Urothelial FGF/FGFR
A Phase 2, Open-label, Single-Agent, Multicenter Study to Evaluate the Efficacy and Safety of INCB054828 in Subjects with Metastatic or Surgically Unresectable Urothelial Carcinoma Haboring FGF/FGFR Alterations Read More
Phase: II
STAR Ph2 enfortumab (ASG-22CE)Urothelial
A single-arm, open-label, multicenter study of enfortumab vedotin (ASG-22CE) for treatment of patients with locally advanced or metastatic urothelial cancer who previously received immune checkpoint inhibitor (CPI) therapy - SGN22E-001 Read More
Phase: II