Focal vs. Craniospinal Irradiation in Multi-Modality Therapy for Atypical Teratoid/Rhabdoid Tumor (ATRT): Results from the Pediatric Proton/Photon Consortium Registry
On Nov. 1, 2021, the International Journal of Radiation Oncology, Biology, Physics published the results of an assessment that examines optimal radiation therapy – comparing craniospinal irradiation (CSI) or focal field – used to treat atypical teratoid rhabdoid tumors (ATRTs).
On Nov. 1, 2021, the International Journal of Radiation Oncology, Biology, Physics published the results of an assessment that examines optimal radiation therapy – comparing craniospinal irradiation (CSI) or focal field – used to treat atypical teratoid rhabdoid tumors (ATRTs). The study evaluated treatment in 65 pediatric patients across 19 institutions chronicled in the Pediatric Proton/Photon Consortium Registry (PPCR). Tumor, treatment, and outcome data were compiled to assess the impact of radiation therapy dose and volume, and an overall survival analysis was performed using the Kaplan Meier method, with the reverse Kaplan Meier method implemented for median follow-up. The findings showed that practice patterns strongly favored focal RT and 54Gy improved local control. Further studies are warranted and in progress.