Brain Substructure-Informed Radiotherapy Planning May Improve Neurocognitive Outcomes in Pediatric Patients with Medulloblastoma
This article outlines the results of a phase III clinical trial, originally reported in the Journal of Clinical Oncology, which demonstrated an increase in neurocognitive impairment outcomes in pediatric patients undergoing radiation therapy for medulloblastoma, specifically when increasing radiotherapy doses to the cerebral cortex or frontal white matter and hippocampus.
This article outlines the results of a phase III clinical trial, originally reported in the Journal of Clinical Oncology, which demonstrated an increase in neurocognitive impairment outcomes in pediatric patients undergoing radiation therapy for medulloblastoma, specifically when increasing radiotherapy doses to the cerebral cortex or frontal white matter and hippocampus. The implications of the study are significant, underscoring the need for targeted proton-beam therapy to potentially mitigate or eliminate cognitive declines in pediatric patients with medulloblastoma by implementing brain substructure- informed radiotherapy planning techniques.