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Randomized Phase IIB Trial of Proton Beam Therapy Versus Intensity-Modulated Radiation Therapy for Locally Advanced Esophageal Cancer

A randomized trial of patients with esophageal cancer compared total toxicity burden and progression-free survival between two modalities: intensity-modulated radiation therapy (IMRT) and proton beam therapy.
Publication

Journal of Clinical Oncology

July 25, 2020

Contributed by:

Lin, Steven H., et al.

A randomized trial of patients with esophageal cancer compared total toxicity burden and progression-free survival between two modalities: intensity-modulated radiation therapy (IMRT) and proton beam therapy. Total toxicity burden rates were lower for patients treated with proton beam therapy versus IMRT, concluding that for locally advanced esophageal cancer, proton beam therapy reduced the risk and severity of adverse events compared with IMRT.