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Comparative Effectiveness of Proton vs. Photon Therapy as Part of Concurrent Chemoradiotherapy for Locally Advanced Cancer

In this analysis, the authors evaluated 1,483 adults with nonmetastatic cancer for the risk of severe adverse events associated with unplanned hospitalizations with concurrent proton-based chemoradiotherapy for patients undergoing conventional photon radiotherapy.
Publication

Journal of the American Medical Association

December 26, 2019

Contributed by:

Baumann, Brian C., Mitra, N., Harton, Joanna G., et al.

In this analysis, the authors evaluated 1,483 adults with nonmetastatic cancer for the risk of severe adverse events associated with unplanned hospitalizations with concurrent proton-based chemoradiotherapy for patients undergoing conventional photon radiotherapy. The findings suggest that proton-based chemoradiotherapy was associated with significantly reduced adverse events that caused unplanned hospitalizations, with similar disease-free and overall survival.